Neonatal invasive group B streptococcus infection, over a 10 year period, in West Hertfordshire, UK
<h4>Introduction</h4> <p>Group B Streptococcus (GBS) infection is the most important cause of neonatal infection in developed and developing countries. UK National guidance for the prevention of neonatal GBS infection was published in 2003 and updated in 2012. This surveillance st...
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| Формат: | Journal article |
| Опубликовано: |
Allied Academies
2017
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| _version_ | 1826280860840624128 |
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| author | Rodrigues, C Parida, S Narayanan, S |
| author_facet | Rodrigues, C Parida, S Narayanan, S |
| author_sort | Rodrigues, C |
| collection | OXFORD |
| description | <h4>Introduction</h4> <p>Group B Streptococcus (GBS) infection is the most important cause of neonatal infection in developed and developing countries. UK National guidance for the prevention of neonatal GBS infection was published in 2003 and updated in 2012. This surveillance study aimed to assess the burden of invasive neonatal GBS disease over a decade in a single UK county.</p> <h4>Method</h4> <p>A retrospective analysis was done of GBS positive cultures from blood and cerebrospinal fluid in babies aged 0-89 days, from 1 January, 2004 to 1 January, 2014. Notes were reviewed and a standard proforma completed by a clinician to identify patient demographics, clinical features, clinical course, treatment and outcome.</p> <h4>Results</h4> <p>There were 41 cases of GBS disease, with an overall incidence of 0.73 per 1000 live births and 17% (n=7) had GBS meningitis. Intrapartum antibiotic prophylaxis was given to 25% (n=4) of eligible mothers. Treatment was for appropriate duration, with exception for severe clinical features. The outcome of GBS meningitis was favourable, with 14% mortality.</p> <h4>Conclusion</h4> <p>The rates of early onset disease 0.44 per 1000, and late onset disease 0.28 per 1000 live births, are in keeping with other national studies of UK incidence. However, this trend is increasing and improvements are needed for better prevention of GBS disease.</p> |
| first_indexed | 2024-03-07T00:20:05Z |
| format | Journal article |
| id | oxford-uuid:7c3b47d7-e281-4872-86f2-0fcb6fc6f711 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T00:20:05Z |
| publishDate | 2017 |
| publisher | Allied Academies |
| record_format | dspace |
| spelling | oxford-uuid:7c3b47d7-e281-4872-86f2-0fcb6fc6f7112022-03-26T20:55:50ZNeonatal invasive group B streptococcus infection, over a 10 year period, in West Hertfordshire, UKJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7c3b47d7-e281-4872-86f2-0fcb6fc6f711Symplectic Elements at OxfordAllied Academies2017Rodrigues, CParida, SNarayanan, S <h4>Introduction</h4> <p>Group B Streptococcus (GBS) infection is the most important cause of neonatal infection in developed and developing countries. UK National guidance for the prevention of neonatal GBS infection was published in 2003 and updated in 2012. This surveillance study aimed to assess the burden of invasive neonatal GBS disease over a decade in a single UK county.</p> <h4>Method</h4> <p>A retrospective analysis was done of GBS positive cultures from blood and cerebrospinal fluid in babies aged 0-89 days, from 1 January, 2004 to 1 January, 2014. Notes were reviewed and a standard proforma completed by a clinician to identify patient demographics, clinical features, clinical course, treatment and outcome.</p> <h4>Results</h4> <p>There were 41 cases of GBS disease, with an overall incidence of 0.73 per 1000 live births and 17% (n=7) had GBS meningitis. Intrapartum antibiotic prophylaxis was given to 25% (n=4) of eligible mothers. Treatment was for appropriate duration, with exception for severe clinical features. The outcome of GBS meningitis was favourable, with 14% mortality.</p> <h4>Conclusion</h4> <p>The rates of early onset disease 0.44 per 1000, and late onset disease 0.28 per 1000 live births, are in keeping with other national studies of UK incidence. However, this trend is increasing and improvements are needed for better prevention of GBS disease.</p> |
| spellingShingle | Rodrigues, C Parida, S Narayanan, S Neonatal invasive group B streptococcus infection, over a 10 year period, in West Hertfordshire, UK |
| title | Neonatal invasive group B streptococcus infection, over a 10 year period, in West Hertfordshire, UK |
| title_full | Neonatal invasive group B streptococcus infection, over a 10 year period, in West Hertfordshire, UK |
| title_fullStr | Neonatal invasive group B streptococcus infection, over a 10 year period, in West Hertfordshire, UK |
| title_full_unstemmed | Neonatal invasive group B streptococcus infection, over a 10 year period, in West Hertfordshire, UK |
| title_short | Neonatal invasive group B streptococcus infection, over a 10 year period, in West Hertfordshire, UK |
| title_sort | neonatal invasive group b streptococcus infection over a 10 year period in west hertfordshire uk |
| work_keys_str_mv | AT rodriguesc neonatalinvasivegroupbstreptococcusinfectionovera10yearperiodinwesthertfordshireuk AT paridas neonatalinvasivegroupbstreptococcusinfectionovera10yearperiodinwesthertfordshireuk AT narayanans neonatalinvasivegroupbstreptococcusinfectionovera10yearperiodinwesthertfordshireuk |