Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing

Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing

Hematopoietic ageing involves declining erythropoiesis and lymphopoiesis, leading to frequent anaemia and decreased adaptive immunity. How intrinsic changes to the hematopoietic stem cells (HSCs), an altered microenvironment and systemic factors contribute to this process is not fully understood. He...

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Detalhes bibliográficos
Principais autores:	Valletta, S, Thomas, A, Meng, Y, Ren, X, Drissen, R, Sengül, H, Di Genua, C, Nerlov, C
Formato:	Journal article
Idioma:	English
Publicado em:	Nature Research 2020

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