Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria
A retrospective study of 100 Malawian children (87 with malaria and 13 with a diagnosis other than malaria) was conducted to determine the relationship between levels of metabolites of the kynurenine pathway in cerebrospinal fluid (CSF) and disease outcome. Three metabolites were measured: quinolini...
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| Format: | Journal article |
| Sprache: | English |
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University of Chicago Press
2003
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| _version_ | 1826280881190338560 |
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| author | Medana, I Day, N Salahifar-Sabet, H Stocker, R Smythe, G Bwanaisa, L Njobvu, A Kayira, K Turner, G Taylor, T Hunt, N |
| author2 | The Infectious Diseases Society of America |
| author_facet | The Infectious Diseases Society of America Medana, I Day, N Salahifar-Sabet, H Stocker, R Smythe, G Bwanaisa, L Njobvu, A Kayira, K Turner, G Taylor, T Hunt, N |
| author_sort | Medana, I |
| collection | OXFORD |
| description | A retrospective study of 100 Malawian children (87 with malaria and 13 with a diagnosis other than malaria) was conducted to determine the relationship between levels of metabolites of the kynurenine pathway in cerebrospinal fluid (CSF) and disease outcome. Three metabolites were measured: quinolinic acid (QA), an excitotoxin; kynurenic acid (KA), a neuroprotective receptor antagonist; a picolinic acid (PA), a proinflammatory mediator. Elevated levels of QA and PA in CSF were associated with a fatal outcome in Malawian children with cerebral malaria (CM). QA was associated with a history of convulsions. An increase in the QA:KA ratio, which favors neurotoxicity, was observed only in the 3 patients with tuberculosis meningitis. Compared with Vietnamese adults with malaria, Malawian children with malaria had higher concentrations of KA. Elevated levels of KA in children with CM may serve to contain brain injury in the developing brain, which is more susceptible to excitotoxic damage than is the adult brain. |
| first_indexed | 2024-03-07T00:20:23Z |
| format | Journal article |
| id | oxford-uuid:7c56da51-9a43-4fcc-bec8-1241d91fc061 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:20:23Z |
| publishDate | 2003 |
| publisher | University of Chicago Press |
| record_format | dspace |
| spelling | oxford-uuid:7c56da51-9a43-4fcc-bec8-1241d91fc0612022-03-26T20:56:28ZMetabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malariaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7c56da51-9a43-4fcc-bec8-1241d91fc061MalariaCerebral malariaClinical laboratory sciencesEnglishOxford University Research Archive - ValetUniversity of Chicago Press2003Medana, IDay, NSalahifar-Sabet, HStocker, RSmythe, GBwanaisa, LNjobvu, AKayira, KTurner, GTaylor, THunt, NThe Infectious Diseases Society of AmericaA retrospective study of 100 Malawian children (87 with malaria and 13 with a diagnosis other than malaria) was conducted to determine the relationship between levels of metabolites of the kynurenine pathway in cerebrospinal fluid (CSF) and disease outcome. Three metabolites were measured: quinolinic acid (QA), an excitotoxin; kynurenic acid (KA), a neuroprotective receptor antagonist; a picolinic acid (PA), a proinflammatory mediator. Elevated levels of QA and PA in CSF were associated with a fatal outcome in Malawian children with cerebral malaria (CM). QA was associated with a history of convulsions. An increase in the QA:KA ratio, which favors neurotoxicity, was observed only in the 3 patients with tuberculosis meningitis. Compared with Vietnamese adults with malaria, Malawian children with malaria had higher concentrations of KA. Elevated levels of KA in children with CM may serve to contain brain injury in the developing brain, which is more susceptible to excitotoxic damage than is the adult brain. |
| spellingShingle | Malaria Cerebral malaria Clinical laboratory sciences Medana, I Day, N Salahifar-Sabet, H Stocker, R Smythe, G Bwanaisa, L Njobvu, A Kayira, K Turner, G Taylor, T Hunt, N Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria |
| title | Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria |
| title_full | Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria |
| title_fullStr | Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria |
| title_full_unstemmed | Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria |
| title_short | Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria |
| title_sort | metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of malawian children with malaria |
| topic | Malaria Cerebral malaria Clinical laboratory sciences |
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