NRAS, FLT3 and TP53 mutations in patients with myelodysplastic syndrome and a del(5q).

NRAS, FLT3 and TP53 mutations in patients with myelodysplastic syndrome and a del(5q).

Mutations of the NRAS and TP53 genes and internal tandem duplication (ITD) of the FLT3 gene are among the most frequently observed molecular abnormalities in the myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). We sought to determine the incidence of these abnormalities in patients...

Full description

Bibliographic Details
Main Authors:	Fidler, C, Watkins, F, Bowen, D, Littlewood, T, Wainscoat, J, Boultwood, J
Format:	Journal article
Language:	English
Published:	2004

Similar Items

The role and impact of Del(5q) and TP53 mutations on haematopoietic stem and progenitor cells during the progression of Myelodysplastic Syndrome to Acute Myeloid Leukaemia
by: Doolittle, H
Published: (2017)

Mutations in PTPN11 are rare in adult myelodysplastic syndromes and acute myeloid leukemia.
by: Watkins, F, et al.
Published: (2004)

TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups
by: Haase, D, et al.
Published: (2019)

Expression profiling of CD34+cells in patients with myelodysplastic syndromes with and without a del(5q).
by: Pellagatti, A, et al.
Published: (2004)

Telomere length in myelodysplastic syndromes.
by: Boultwood, J, et al.
Published: (1995)

Gene expression profiling in patients with myelodysplastic syndromes, including patients with the del(5q)
by: Boultwood, J
Published: (2009)

Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes
by: Bernard, E, et al.
Published: (2020)

Targeted re-sequencing analysis of 25 genes commonly mutated in myeloid disorders in del(5q) myelodysplastic syndromes.
by: Fernandez-Mercado, M, et al.
Published: (2013)

8 Gene expression profiling in patients with myelodysplastic syndromes, including patients with the del(5q)
by: Boultwood, J
Published: (2009)

Gene expression profiling in 5q-syndrome and myelodysplastic syndromes.
by: Pellagatti, A, et al.
Published: (2003)

TP53-mutated myelodysplastic syndrome and acute myeloid leukemia: biology, current therapy, and future directions
by: Daver, NG, et al.
Published: (2022)

Marked down-regulation of nucleophosmin-1 is associated with advanced del(5q) myelodysplastic syndrome.
by: Pellagatti, A, et al.
Published: (2011)

Marked down-regulation of nucleophosmin-1 is associated with advanced del(5q) myelodysplastic syndrome
by: Pellagatti, A, et al.
Published: (2011)

Expression profiling of CD34+cells in patients with myelodysplastic syndromes with and without a del(5q)
by: Pellagatti, A, et al.
Published: (2005)

Gene expression profiling in the myelodysplastic syndromes.
by: Pellagatti, A, et al.
Published: (2005)

Clonality in the myelodysplastic syndromes.
by: Boultwood, J, et al.
Published: (2001)

Genome-wide analysis of copy number change and loss of heterozygosity in myelodysplastic syndrome with del(5q) using high-density SNP arrays
by: Wang, L, et al.
Published: (2007)

Molecular pathogenesis of the myelodysplastic syndromes
by: Boultwood, J, et al.
Published: (1999)

Whole-exome sequencing in del(5q) myelodysplastic syndromes in transformation to acute myeloid leukemia
by: Pellagatti, A, et al.
Published: (2014)

Whole-exome sequencing in del(5q) myelodysplastic syndromes in transformation to acute myeloid leukemia.
by: Pellagatti, A, et al.
Published: (2014)

Progression in patients with low- and intermediate1-risk del(5q) myelodysplastic syndromes is predicted by a limited subset of mutations.
by: Scharenberg, C, et al.
Published: (2016)

Genome-wide analysis of copy number changes and loss of heterozygosity in myelodysplastic syndrome with del(5q) using high-density single nucleotide polymorphism arrays.
by: Wang, L, et al.
Published: (2008)

Telomere length in myelodysplastic syndromes.
by: Boultwood, J, et al.
Published: (1997)

Unravelling haematopoietic stem cell dysfunction in isolated Del(5q) myelodysplastic syndromes
by: Stenson, L
Published: (2015)

FLT3, NPM1, DNMT3a and NRAS genes mutation in acute myeloid leukaemia in HUSM
by: Mat Yunus, Noraini
Published: (2015)

TP53 suppression promotes erythropoiesis in del(5q) MDS, suggesting a targeted therapeutic strategy in lenalidomide-resistant patients.
by: Caceres, G, et al.
Published: (2013)

L-leucine increases translation of RPS14 and LARP1 in erythroblasts from del(5q) myelodysplastic syndrome patients
by: Bello, E, et al.
Published: (2018)

The role of splicing factor mutations in the pathogenesis of the myelodysplastic syndromes.
by: Boultwood, J, et al.
Published: (2014)

Mutation analysis of the SPARC gene in the 5q-syndrome.
by: Fidler, C, et al.
Published: (2000)

MOLECULAR DELINEATION OF THE CRITICAL REGION OF THE 5Q-CHROMOSOME IN THE 5Q-SYNDROME
by: Boultwood, J, et al.
Published: (1993)

Low expression of the putative tumour suppressor gene gravin in chronic myeloid leukaemia, myelodysplastic syndromes and acute myeloid leukaemia.
by: Boultwood, J, et al.
Published: (2004)

GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR GENE IN MYELODYSPLASTIC SYNDROMES - REPLY
by: Boultwood, J, et al.
Published: (1991)

Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms.
by: Malcovati, L, et al.
Published: (2011)

MOLECULAR MAPPING OF UNCHARACTERISTICALLY SMALL 5Q DELETIONS IN 2 PATIENTS WITH THE 5Q- SYNDROME - DELINEATION OF THE CRITICAL REGION ON 5Q AND IDENTIFICATION OF A 5Q- BREAKPOINT
by: Boultwood, J, et al.
Published: (1993)

Molecular mapping of uncharacteristically small 5q deletions in two patients with the 5q- syndrome: delineation of the critical region on 5q and identification of a 5q- breakpoint.
by: Boultwood, J, et al.
Published: (1994)

Hematological features of patients with myelodysplastic syndromes associated with a chromosome 5q deletion.
by: Lewis, S, et al.
Published: (1995)

Haploinsufficiency of ribosomal proteins and p53 activation in anemia: Diamond-Blackfan anemia and the 5q- syndrome.
by: Boultwood, J, et al.
Published: (2012)

The 5q-syndrome.
by: Boultwood, J, et al.
Published: (1994)

Induction of p53 and up-regulation of the p53 pathway in the human 5q- syndrome.
by: Pellagatti, A, et al.
Published: (2010)

Non-del(5q) myelodysplastic syndromes-associated loci detected by SNP-array genome-wide association meta-analysis
by: McGraw, KL, et al.
Published: (2019)