Identification and development of 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one inhibitors targeting bromodomains within the switch/sucrose non-fermenting complex.

Identification and development of 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one inhibitors targeting bromodomains within the switch/sucrose non-fermenting complex.

Pokaż inne wersje (1)

Bromodomain containing proteins PB1, SMARCA4, and SMARCA2 are important components of SWI/SNF chromatin remodeling complexes. We identified bromodomain inhibitors targeting these proteins, which display unusual binding modes involving water displacement from the KAc binding site. The best compound b...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Sutherell, C, Tallant, C, Monteiro, O, Yapp, C, Fuchs, J, Fedorov, O, Siejka, P, Müller, S, Knapp, S, Brenton, J, Brennan, P, Ley, S
Format: Journal article
Język:English
Wydane: American Chemical Society 2016

Podobne zapisy