Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition.

Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition.

It is well established that all of the cis-acting sequences required for fully regulated human alpha-globin expression are contained within a region of approximately 120 kb of conserved synteny. Here, we show that activation of this cluster in erythroid cells dramatically affects expression of appar...

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Bibliografiska uppgifter
Huvudupphovsmän:	Lower, K, Hughes, J, De Gobbi, M, Henderson, S, Viprakasit, V, Fisher, C, Goriely, A, Ayyub, H, Sloane-Stanley, J, Vernimmen, D, Langford, C, Garrick, D, Gibbons, R, Higgs, D
Materialtyp:	Journal article
Språk:	English
Publicerad:	2009

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