Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition.
It is well established that all of the cis-acting sequences required for fully regulated human alpha-globin expression are contained within a region of approximately 120 kb of conserved synteny. Here, we show that activation of this cluster in erythroid cells dramatically affects expression of appar...
| المؤلفون الرئيسيون: | , , , , , , , , , , , , , |
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| التنسيق: | Journal article |
| اللغة: | English |
| منشور في: |
2009
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