The application of deconvolution analysis to elucidate the pulsatile nature of growth hormone secretion using a variable half-life of growth hormone.
A deconvolution analysis model to calculate pituitary growth hormone (GH) secretion rate from measured serum GH concentration has been developed. This uses an iterative method of 'curve-stripping' based on an estimate of the half-life. The model has been applied to serum GH profiles and de...
Main Authors: | Hindmarsh, P, Matthews, DR, Brain, C, Pringle, P, Brook, C |
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Format: | Journal article |
Language: | English |
Published: |
1990
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