Sickle-cell disease.

Sickle-cell disease.

Sickle-cell disease is one of the most common severe monogenic disorders in the world. Haemoglobin polymerisation, leading to erythrocyte rigidity and vaso-occlusion, is central to the pathophysiology of this disease, although the importance of chronic anaemia, haemolysis, and vasculopathy has been...

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Autori principali:	Rees, D, Williams, T, Gladwin, M
Natura:	Journal article
Lingua:	English
Pubblicazione:	2010

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