Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP.

Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP.

Little is known about the processing of putative human autoantigens and why tolerance is established to some T cell epitopes but not others. Here we show that a principal human HLA-DR2-restricted epitope--amino acids 85-99 of myelin basic protein, MBP(85-99)--contains a processing site for the cyste...

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Bibliographic Details
Main Authors: Manoury, B, Mazzeo, D, Fugger, L, Viner, N, Ponsford, M, Streeter, H, Mazza, G, Wraith, D, Watts, C
Format: Journal article
Language:English
Published: 2002

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