Repopulating microglia promote brain repair in an IL-6-dependent manner
Cognitive dysfunction and reactive microglia are hallmarks of traumatic brain injury (TBI), yet whether these cells contribute to cognitive deficits and secondary inflammatory pathology remains poorly understood. Here, we show that removal of microglia from the mouse brain has little effect on the o...
Autores principales: | Willis, EF, MacDonald, KPA, Nguyen, QH, Garrido, AL, Gillespie, ER, Harley, SBR, Bartlett, PF, Schroder, WA, Yates, AG, Anthony, DC, Rose-John, S, Ruitenberg, MJ, Vukovic, J |
---|---|
Formato: | Journal article |
Lenguaje: | English |
Publicado: |
Cell Press
2020
|
Ejemplares similares
-
Exercise rejuvenates microglia and reverses T cell accumulation in the aged female mouse brain
por: Chauquet, S, et al.
Publicado: (2024) -
Protocol for brain-wide or region-specific microglia depletion and repopulation in adult mice
por: Emily F. Willis, et al.
Publicado: (2020-12-01) -
Acute IL-1RA treatment suppresses the peripheral and central inflammatory response to spinal cord injury
por: Yates, AG, et al.
Publicado: (2021) -
Tracking changes in functionality and morphology of repopulated microglia in young and old mice
por: Zuzanna M. Luczak-Sobotkowska, et al.
Publicado: (2024-10-01) -
Systemic immune response to traumatic CNS injuries—are extracellular vesicles the missing link?
por: Yates, AG, et al.
Publicado: (2019)