PET tau and amyloid-β burden in mild Alzheimer's disease: divergent relationship with age, cognition and cerebrospinal fluid biomarkers
<strong>Background</strong> Combining PET amyloid-β and tau imaging may be critical for tracking disease progression in Alzheimer’s disease (AD). <strong>Objective</strong> We sought to characterize the relationship between amyloid-β and tau ligands as well as with other meas...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
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IOS Press
2017
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| _version_ | 1797077689176162304 |
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| author | Koychev, I Gunn, R Firouzian, A Lawson, J Zamboni, G Ridha, B Sahakian, B Rowe, J Howard, R Zetterberg, H Mackay, C Lovestone, S |
| author_facet | Koychev, I Gunn, R Firouzian, A Lawson, J Zamboni, G Ridha, B Sahakian, B Rowe, J Howard, R Zetterberg, H Mackay, C Lovestone, S |
| author_sort | Koychev, I |
| collection | OXFORD |
| description | <strong>Background</strong> Combining PET amyloid-β and tau imaging may be critical for tracking disease progression in Alzheimer’s disease (AD). <strong>Objective</strong> We sought to characterize the relationship between amyloid-β and tau ligands as well as with other measures of pathology. <strong>Methods</strong> We conducted a multi-center observational study in early AD (MMSE >20) participants aged 50 to 85 years. The schedule included cognitive assessments (ADAS-Cog) and CSF measurement of Aβ and tau at baseline and 6 months; PET-CT imaging with amyloid-β ([18F]AV45) and tau ([18F]AV1451) ligands at baseline. <strong>Results</strong> 22 participants took part in the study with 20 completing its 6-month duration and 12 having both tau and amyloid PET. The PET biomarker analysis revealed a strong negative correlation between age and tau in multiple regions. Entorhinal cortex tau and age interacted significantly in terms of cognitive change over 6 months which may have been to older participants deteriorating faster despite lower levels of cortical tau. Cortical amyloid-β associated with entorhinal cortex tau while CSF tau/Aβ ratio correlated strongly with cortical tau but not amyloid-β. <strong>Conclusion</strong> The negative relationship between age and cortical tau whereby younger patients with mild AD had relatively greater tau burden is potentially important. It suggests that younger-age onset AD may be primarily driven by tau pathology while AD developing later may depend on a multitude of pathological mechanisms. These data also suggest that PET-tau performs better than PET-amyloid in predicting the best validated AD diagnostic marker – the CSF total tau/Aβratio. |
| first_indexed | 2024-03-07T00:21:35Z |
| format | Journal article |
| id | oxford-uuid:7cbadd7a-5f6e-4a70-a6fb-b8f4073880c4 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T00:21:35Z |
| publishDate | 2017 |
| publisher | IOS Press |
| record_format | dspace |
| spelling | oxford-uuid:7cbadd7a-5f6e-4a70-a6fb-b8f4073880c42022-03-26T20:59:07ZPET tau and amyloid-β burden in mild Alzheimer's disease: divergent relationship with age, cognition and cerebrospinal fluid biomarkersJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7cbadd7a-5f6e-4a70-a6fb-b8f4073880c4Symplectic Elements at OxfordIOS Press2017Koychev, IGunn, RFirouzian, ALawson, JZamboni, GRidha, BSahakian, BRowe, JHoward, RZetterberg, HMackay, CLovestone, S<strong>Background</strong> Combining PET amyloid-β and tau imaging may be critical for tracking disease progression in Alzheimer’s disease (AD). <strong>Objective</strong> We sought to characterize the relationship between amyloid-β and tau ligands as well as with other measures of pathology. <strong>Methods</strong> We conducted a multi-center observational study in early AD (MMSE >20) participants aged 50 to 85 years. The schedule included cognitive assessments (ADAS-Cog) and CSF measurement of Aβ and tau at baseline and 6 months; PET-CT imaging with amyloid-β ([18F]AV45) and tau ([18F]AV1451) ligands at baseline. <strong>Results</strong> 22 participants took part in the study with 20 completing its 6-month duration and 12 having both tau and amyloid PET. The PET biomarker analysis revealed a strong negative correlation between age and tau in multiple regions. Entorhinal cortex tau and age interacted significantly in terms of cognitive change over 6 months which may have been to older participants deteriorating faster despite lower levels of cortical tau. Cortical amyloid-β associated with entorhinal cortex tau while CSF tau/Aβ ratio correlated strongly with cortical tau but not amyloid-β. <strong>Conclusion</strong> The negative relationship between age and cortical tau whereby younger patients with mild AD had relatively greater tau burden is potentially important. It suggests that younger-age onset AD may be primarily driven by tau pathology while AD developing later may depend on a multitude of pathological mechanisms. These data also suggest that PET-tau performs better than PET-amyloid in predicting the best validated AD diagnostic marker – the CSF total tau/Aβratio. |
| spellingShingle | Koychev, I Gunn, R Firouzian, A Lawson, J Zamboni, G Ridha, B Sahakian, B Rowe, J Howard, R Zetterberg, H Mackay, C Lovestone, S PET tau and amyloid-β burden in mild Alzheimer's disease: divergent relationship with age, cognition and cerebrospinal fluid biomarkers |
| title | PET tau and amyloid-β burden in mild Alzheimer's disease: divergent relationship with age, cognition and cerebrospinal fluid biomarkers |
| title_full | PET tau and amyloid-β burden in mild Alzheimer's disease: divergent relationship with age, cognition and cerebrospinal fluid biomarkers |
| title_fullStr | PET tau and amyloid-β burden in mild Alzheimer's disease: divergent relationship with age, cognition and cerebrospinal fluid biomarkers |
| title_full_unstemmed | PET tau and amyloid-β burden in mild Alzheimer's disease: divergent relationship with age, cognition and cerebrospinal fluid biomarkers |
| title_short | PET tau and amyloid-β burden in mild Alzheimer's disease: divergent relationship with age, cognition and cerebrospinal fluid biomarkers |
| title_sort | pet tau and amyloid β burden in mild alzheimer s disease divergent relationship with age cognition and cerebrospinal fluid biomarkers |
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