Complete versus incomplete surgical resection in intramedullary astrocytoma: systematic review with individual patient data meta-analysis
<p><strong>Study Design</strong></p> Systematic review <br> Background: Considering the infiltrative nature of intramedullary astrocytoma, the goal of surgery is to have a better patient related outcome. <p><strong>Objective</strong></p> To comp...
| Hoofdauteurs: | , , , , , , , , , |
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| Formaat: | Journal article |
| Taal: | English |
| Gepubliceerd in: |
SAGE Publications
2022
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| _version_ | 1826311637834924032 |
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| author | Golpayegani, M Edalatfar, M Ahmadi, A Sadeghi-Naini, M Salari, F Hanaei, S Shokraneh, F Ghodsi, Z Vaccaro, AR Rahimi-Movaghar, V |
| author_facet | Golpayegani, M Edalatfar, M Ahmadi, A Sadeghi-Naini, M Salari, F Hanaei, S Shokraneh, F Ghodsi, Z Vaccaro, AR Rahimi-Movaghar, V |
| author_sort | Golpayegani, M |
| collection | OXFORD |
| description | <p><strong>Study Design</strong></p>
Systematic review
<br>
Background: Considering the infiltrative nature of intramedullary astrocytoma, the goal of surgery is to have a better patient related outcome.
<p><strong>Objective</strong></p>
To compare the overall survival (OS) and neurologic outcomes of complete vs incomplete surgical resection for patients with intramedullary astrocytoma.
<p><strong>Methods</strong></p>
A comprehensive search of MEDLINE, CENTRAL and EMBASE was conducted by two independent reviewers. Individual patient data (IPD) analysis and multivariate Cox Proportional Hazard Model was developed to measure the effect of surgical strategies on OS, post-operative neurological improvement (PNI), and neurological improvement in the last follow up (FNI).
<p><strong>Results</strong></p>
We included 1079 patients from 35 studies. Individual patient data of 228 patients (13 articles) was incorporated into the integrative IPD analysis. Kaplan-Meier survival analysis showed complete resection (CR) significantly improved OS in comparison with the incomplete resection (IR) (log-rank test, P = .004). In the multivariate IPD analysis, three prognostic factors had significant effect on the OS: (1) Extent of Resection, (2) pathology grade, and (3) adjuvant therapy. We observed an upward trend in the popularity of chemotherapy, but CR, IR, and radiotherapy had relatively stable trends during three decades.
<p><strong>Conclusion</strong></p>
Our study shows that CR can improve OS when compared to IR. Patients with spinal cord astrocytoma undergoing CR had similar PNI and FNI compared to IR. Therefore, CR should be the primary goal of surgery, but intraoperative decisions on the extent of resection should be relied on to prevent neurologic adverse events. Due to significant effect of adjuvant therapy on OS, PNI and FNI, it could be considered as the routine treatment strategy for spinal cord astrocytoma. |
| first_indexed | 2024-03-07T08:12:44Z |
| format | Journal article |
| id | oxford-uuid:7cd14dc4-d4d7-4d71-8d09-8a91485e37b7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:12:44Z |
| publishDate | 2022 |
| publisher | SAGE Publications |
| record_format | dspace |
| spelling | oxford-uuid:7cd14dc4-d4d7-4d71-8d09-8a91485e37b72023-12-08T14:49:03ZComplete versus incomplete surgical resection in intramedullary astrocytoma: systematic review with individual patient data meta-analysisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7cd14dc4-d4d7-4d71-8d09-8a91485e37b7EnglishSymplectic ElementsSAGE Publications2022Golpayegani, MEdalatfar, MAhmadi, ASadeghi-Naini, MSalari, FHanaei, SShokraneh, FGhodsi, ZVaccaro, ARRahimi-Movaghar, V<p><strong>Study Design</strong></p> Systematic review <br> Background: Considering the infiltrative nature of intramedullary astrocytoma, the goal of surgery is to have a better patient related outcome. <p><strong>Objective</strong></p> To compare the overall survival (OS) and neurologic outcomes of complete vs incomplete surgical resection for patients with intramedullary astrocytoma. <p><strong>Methods</strong></p> A comprehensive search of MEDLINE, CENTRAL and EMBASE was conducted by two independent reviewers. Individual patient data (IPD) analysis and multivariate Cox Proportional Hazard Model was developed to measure the effect of surgical strategies on OS, post-operative neurological improvement (PNI), and neurological improvement in the last follow up (FNI). <p><strong>Results</strong></p> We included 1079 patients from 35 studies. Individual patient data of 228 patients (13 articles) was incorporated into the integrative IPD analysis. Kaplan-Meier survival analysis showed complete resection (CR) significantly improved OS in comparison with the incomplete resection (IR) (log-rank test, P = .004). In the multivariate IPD analysis, three prognostic factors had significant effect on the OS: (1) Extent of Resection, (2) pathology grade, and (3) adjuvant therapy. We observed an upward trend in the popularity of chemotherapy, but CR, IR, and radiotherapy had relatively stable trends during three decades. <p><strong>Conclusion</strong></p> Our study shows that CR can improve OS when compared to IR. Patients with spinal cord astrocytoma undergoing CR had similar PNI and FNI compared to IR. Therefore, CR should be the primary goal of surgery, but intraoperative decisions on the extent of resection should be relied on to prevent neurologic adverse events. Due to significant effect of adjuvant therapy on OS, PNI and FNI, it could be considered as the routine treatment strategy for spinal cord astrocytoma. |
| spellingShingle | Golpayegani, M Edalatfar, M Ahmadi, A Sadeghi-Naini, M Salari, F Hanaei, S Shokraneh, F Ghodsi, Z Vaccaro, AR Rahimi-Movaghar, V Complete versus incomplete surgical resection in intramedullary astrocytoma: systematic review with individual patient data meta-analysis |
| title | Complete versus incomplete surgical resection in intramedullary astrocytoma: systematic review with individual patient data meta-analysis |
| title_full | Complete versus incomplete surgical resection in intramedullary astrocytoma: systematic review with individual patient data meta-analysis |
| title_fullStr | Complete versus incomplete surgical resection in intramedullary astrocytoma: systematic review with individual patient data meta-analysis |
| title_full_unstemmed | Complete versus incomplete surgical resection in intramedullary astrocytoma: systematic review with individual patient data meta-analysis |
| title_short | Complete versus incomplete surgical resection in intramedullary astrocytoma: systematic review with individual patient data meta-analysis |
| title_sort | complete versus incomplete surgical resection in intramedullary astrocytoma systematic review with individual patient data meta analysis |
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