Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

Бусад хувилбаруудыг харуулах (1)

Type 2 diabetes affects over 300 million people, causing severe complications and premature death, yet the underlying molecular mechanisms are largely unknown. Pancreatic islet dysfunction is central in type 2 diabetes pathogenesis, and understanding islet genome regulation could therefore provide v...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Pasquali, L, Gaulton, K, Rodríguez-Seguí, SA, Mularoni, L, Miguel-Escalada, I, Akerman, I, Tena, J, Morán, I, Gómez-Marín, C, Van De Bunt, M, Ponsa-Cobas, J, Castro, N, Nammo, T, Cebola, I, García-Hurtado, J, Maestro, M, Pattou, F, Piemonti, L, Berney, T, Gloyn, A, Ravassard, P, Skarmeta, J, Müller, F, Mccarthy, M, Ferrer, J
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	Nature Publishing Group 2014

Ижил төстэй зүйлс

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants.
-н: Pasquali, L, зэрэг
Хэвлэсэн: (2014)

The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis
-н: Van De Bunt, M, зэрэг
Хэвлэсэн: (2013)

Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes.
-н: Morán, I, зэрэг
Хэвлэсэн: (2012)

The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis.
-н: Martijn van de Bunt, зэрэг
Хэвлэсэн: (2013-01-01)

MiR-184 expression is regulated by AMPK in pancreatic islets
-н: Martinez-Sanchez, A, зэрэг
Хэвлэсэн: (2017)

Genetic regulation of RNA splicing in human pancreatic islets
-н: Goutham Atla, зэрэг
Хэвлэсэн: (2022-09-01)

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci
-н: Matthias Thurner, зэрэг
Хэвлэсэн: (2018-02-01)

Insights into β-cell biology and type 2 diabetes pathogenesis from studies of the islet transcriptome
-н: Van De Bunt, M, зэрэг
Хэвлэсэн: (2014)

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci
-н: Thurner, M, зэрэг
Хэвлэсэн: (2018)

Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells [version 2; peer review: 2 approved]
-н: Jason M. Torres, зэрэг
Хэвлэсэн: (2023-08-01)

Article Commentary: Islet Transplantation
-н: Thierry Berney, зэрэг
Хэвлэсэн: (1999-09-01)

Homeostatic T Cell Proliferation after Islet Transplantation
-н: Paolo Monti, зэрэг
Хэвлэсэн: (2013-01-01)

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors.
-н: Martijn van de Bunt, зэрэг
Хэвлэсэн: (2015-12-01)

Bone Marrow and Pancreatic Islets: An Old Story with New Perspectives
-н: Fabio Ciceri, зэрэг
Хэвлэсэн: (2010-12-01)

Intrahepatic Islet Transplant in the Mouse: Functional and Morphological Characterization
-н: R. Melzi, зэрэг
Хэвлэсэн: (2008-12-01)

Differentiation of Sendai Virus-Reprogrammed iPSC into β Cells, Compared with Human Pancreatic Islets and Immortalized β Cell Line
-н: Silvia Pellegrini, зэрэг
Хэвлэсэн: (2018-10-01)

Cautious Optimism Warranted for Stem Cell-Derived Islet Transplantation in Type 2 Diabetes
-н: Hanne Scholz, зэрэг
Хэвлэсэн: (2024-07-01)

Insights into islet development and biology through characterization of a human iPSC-derived endocrine pancreas model
-н: van de Bunt, M, зэрэг
Хэвлэсэн: (2016)

Not reimbursing islet transplantation creates discrimination against patients with type 1 diabetes
-н: T. Berney
Хэвлэсэн: (2019-10-01)

Patterns of differential gene expression in a cellular model of human islet development, and relationship to type 2 diabetes predisposition
-н: Perez-Alcantara, M, зэрэг
Хэвлэсэн: (2018)

Mechanisms of genome regulation in human islets and their role in the pathogenesis of type 2 diabetes
-н: van de Bunt, G, зэрэг
Хэвлэсэн: (2014)

Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data
-н: Fernández-Tajes, J, зэрэг
Хэвлэсэн: (2019)

Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data
-н: Juan Fernández-Tajes, зэрэг
Хэвлэсэн: (2019-03-01)

Islet Transplantation – perspective from Poland
-н: A. Dębska-Ślizień, зэрэг
Хэвлэсэн: (2019-11-01)

Donor pancreata: evolving approaches to organ allocation for whole pancreas versus islet transplantation.
-н: Berney, T, зэрэг
Хэвлэсэн: (2010)

Beta cells within single human islets originate from multiple progenitors.
-н: Raphaël Scharfmann, зэрэг
Хэвлэсэн: (2008-01-01)

The Impact of Potential Islet Precursor Cells on Islet Autotransplantation Outcomes
-н: M. A. Webb, зэрэг
Хэвлэсэн: (2013-06-01)

Alginate Microencapsulation of Human Islets Does Not Increase Susceptibility to Acute Hypoxia
-н: I. K. Hals, зэрэг
Хэвлэсэн: (2013-01-01)

Islet Transplantation & β-Cell Replacement Therapies for Diabetes
-н: Thierry Berney, зэрэг
Хэвлэсэн: (2011-01-01)

Does islet size really influence graft function following clinical islet transplantation?
-н: Hughes, S, зэрэг
Хэвлэсэн: (2018)

Synthetic alpha-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation.
-н: Saraogi, I, зэрэг
Хэвлэсэн: (2010)

Mammalian tissue-free liberase: a new GMP-graded enzyme blend for human islet isolation.
-н: Caballero-Corbalán, J, зэрэг
Хэвлэсэн: (2010)

Transcriptional signature of islet neogenesis-associated protein peptide-treated rat pancreatic islets reveals induction of novel long non-coding RNAs
-н: Agustín Romero, зэрэг
Хэвлэсэн: (2023-09-01)

Investigating the role of the recently described Type 2 diabetes associated gene CDKN2A (p16) on pancreatic islet function using a human model of CDKN2A haploinsufficiency (vol 28, pg 53, 2011)
-н: Pal, A, зэрэг
Хэвлэсэн: (2011)

Effects of woodland islets introduced in a Mediterranean agricultural landscape on local bird communities
-н: I. Razola, зэрэг
Хэвлэсэн: (2009-06-01)

Multiplexed CRISPR gene editing in primary human islet cells with Cas9 ribonucleoprotein
-н: Romina J. Bevacqua, зэрэг
Хэвлэсэн: (2024-01-01)

Islet Volume and Indexes of β-Cell Function in Humans
-н: Rita Nano, зэрэг
Хэвлэсэн: (2016-03-01)

Prevalence of GCK mutations in individuals screened for fasting hyperglycaemia.
-н: Gloyn, A, зэрэг
Хэвлэсэн: (2009)

Prevalence of glucokinase (GCK) mutations in people with elevated fasting glucose levels: implications for clinical trials
-н: Gloyn, A, зэрэг
Хэвлэсэн: (2007)

Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene
-н: Ildem Akerman, зэрэг
Хэвлэсэн: (2021-04-01)