MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia

<p>Aberrant enhancer activation is a key mechanism driving oncogene expression in many cancers. While much is known about the regulation of larger chromosome domains in eukaryotes, the details of enhancer-promoter interactions remain poorly understood. Recent work suggests co-activators like B...

Celý popis

Podrobná bibliografie
Hlavní autoři:	Crump, NT, Smith, AL, Godfrey, L, Dopico-Fernandez, AM, Denny, N, Harman, JR, Hamley, JC, Jackson, NE, Chahrour, C, Riva, S, Rice, S, Kim, J, Basrur, V, Fermin, D, Elenitoba-Johnson, K, Roeder, RG, Allis, CD, Roberts, I, Roy, A, Geng, H, Davies, JOJ, Milne, TA
Médium:	Journal article
Jazyk:	English
Vydáno:	Springer Nature 2023

MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia

Podobné jednotky