Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate.
Regulation of the hypoxic response in humans is regulated by the post-translational hydroxylation of hypoxia inducible transcription factor; a recombinant form of a human prolyl-4-hydroxylase (PHD2) was characterised and shown to have an unexpectedly high affinity for, and to copurify with endogenou...
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Bibliographic Details
| Main Authors: |
McNeill, L,
Flashman, E,
Buck, MR,
Hewitson, K,
Clifton, I,
Jeschke, G,
Claridge, T,
Ehrismann, D,
Oldham, N,
Schofield, C |
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| Format: | Journal article
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| Language: | English |
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| Published: |
2005
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