The effect of HLA-DR on susceptibility to rheumatoid arthritis is influenced by the associated lymphotoxin alpha-tumor necrosis factor haplotype.

The effect of HLA-DR on susceptibility to rheumatoid arthritis is influenced by the associated lymphotoxin alpha-tumor necrosis factor haplotype.

OBJECTIVE: HLA-DRB1, a major genetic determinant of susceptibility to rheumatoid arthritis (RA), is located within 1,000 kb of the gene encoding tumor necrosis factor (TNF). Because certain HLA-DRB1*04 subtypes increase susceptibility to RA, investigation of the role of the TNF gene is complicated...

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Bibliografiske detaljer
Main Authors:	Newton, J, Brown, M, Milicic, A, Ackerman, H, Darke, C, Wilson, J, Wordsworth, B, Kwiatkowski, D
Format:	Journal article
Sprog:	English
Udgivet:	2003

Lignende værker

LTA-TNF HAPLOTYPE STUDIES IDENTIFY ADDITIONAL RHEUMATOID ARTHRITIS SUSCEPTIBILITY REGIONS IN THE MHC
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Udgivet: (2002)

HLA-DR/DQ haplotype in rheumatoid arthritis: novel allelic associations in UK Caucasians.
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Udgivet: (2002)

The association of extended TNF haplotypes and susceptibility to rheumatoid arthritis
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Udgivet: (2001)

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Udgivet: (2005)

Arming ColoAd1 with tumor necrosis factor alpha and lymphotoxin alpha
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Udgivet: (2015)

Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations.
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Udgivet: (2009)

The association of INOS promoter haplotypes with rheumatoid arthritis
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Udgivet: (2001)

Anti-tumor necrosis factor-alpha therapy of rheumatoid arthritis.
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Udgivet: (1997)

REFINEMENT OF THE CRH HAPLOTYPE IN RHEUMATOID ARTHRITIS
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Udgivet: (2004)

Dissection of class III major histocompatibility complex haplotypes associated with rheumatoid arthritis.
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Udgivet: (2004)

HLA-DR HETEROZYGOSITY CONTRIBUTES SUSCEPTIBILITY TO SEVERE RHEUMATOID-ARTHRITIS
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Udgivet: (1992)

HLA class II antigens in susceptibility to rheumatoid arthritis.
af: Wordsworth, B
Udgivet: (1991)

The HLA class II component of susceptibility to rheumatoid arthritis.
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Udgivet: (1992)

HLA heterozygosity contributes to susceptibility to rheumatoid arthritis.
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Udgivet: (1992)

Influence of the HLA-DRB1 locus on susceptibility and severity in rheumatoid arthritis.
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Udgivet: (1996)

NON-INHERITED MATERNAL ANTIGENS INFLUENCE SUSCEPTIBILITY TO RHEUMATOID ARTHRITIS
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Udgivet: (2002)

Non-inherited maternal HLA alleles are associated with rheumatoid arthritis.
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Udgivet: (2003)

Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha.
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Udgivet: (2008)

Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha.
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Anti-tumor necrosis factor alpha therapy of rheumatoid arthritis. Mechanism of action.
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Systemic anti-tumor necrosis factor alpha therapy in rheumatoid arthritis down-regulates synovial tumor necrosis factor alpha synthesis.
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Linkage analysis of potential rheumatoid arthritis non-HLA susceptibility loci.
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Udgivet: (2000)

Interleukin 10 (IL-10) haplotypes are associated with rheumatoid arthritis (RA).
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Udgivet: (2000)

THE HLA CLASS II ASSOCIATIONS OF RHEUMATOID-ARTHRITIS CONFER SEVERITY NOT SUSCEPTIBILITY
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Udgivet: (1992)

Deactivation of vascular endothelium by monoclonal anti-tumor necrosis factor alpha antibody in rheumatoid arthritis.
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Udgivet: (1996)

Family-based analysis of tumor necrosis factor and lymphotoxin-alpha tag polymorphisms with type 1 diabetes in the population of South Croatia.
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Udgivet: (2009)

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Udgivet: (1991)

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Localization of tumor necrosis factor alpha in synovial tissues and at the cartilage-pannus junction in patients with rheumatoid arthritis.
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Expression of granulocyte-macrophage colony-stimulating factor in rheumatoid arthritis: regulation by tumor necrosis factor-alpha.
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Udgivet: (1991)

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A GENE INTERACTIVE WITH HLA-DR4 IN SUSCEPTIBILITY TO TYPE-I DIABETES IS NOT INVOLVED IN RHEUMATOID-ARTHRITIS (RA)
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Udgivet: (1992)

Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis.
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Udgivet: (2000)

Similarities in the mechanisms of action of pulse corticosteroids and anti-tumor necrosis factor alpha therapy in rheumatoid arthritis - Reply
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Udgivet: (1998)

Modulation of angiogenic vascular endothelial growth factor by tumor necrosis factor alpha and interleukin-1 in rheumatoid arthritis.
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Udgivet: (1998)

Limited heterogeneity of the HLA class II contribution to susceptibility to rheumatoid arthritis is suggested by positive associations with HLA-DR4, DR1 and DRw10.
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Udgivet: (1991)