The effect of HLA-DR on susceptibility to rheumatoid arthritis is influenced by the associated lymphotoxin alpha-tumor necrosis factor haplotype.

The effect of HLA-DR on susceptibility to rheumatoid arthritis is influenced by the associated lymphotoxin alpha-tumor necrosis factor haplotype.

OBJECTIVE: HLA-DRB1, a major genetic determinant of susceptibility to rheumatoid arthritis (RA), is located within 1,000 kb of the gene encoding tumor necrosis factor (TNF). Because certain HLA-DRB1*04 subtypes increase susceptibility to RA, investigation of the role of the TNF gene is complicated...

Bibliografiset tiedot
Päätekijät:	Newton, J, Brown, M, Milicic, A, Ackerman, H, Darke, C, Wilson, J, Wordsworth, B, Kwiatkowski, D
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	2003

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