Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease.

Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease.

Prion diseases are fatal, chronic neurodegenerative diseases of mammals, characterized by amyloid deposition, astrogliosis, microglial activation, tissue vacuolation and neuronal loss. In the ME7 model of prion disease in the C57BL/6 J mouse, we have shown previously that these animals display behav...

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Bibliographic Details
Main Authors:	Cunningham, C, Deacon, R, Wells, H, Boche, D, Waters, S, Diniz, C, Scott, H, Rawlins, J, Perry, V
Format:	Journal article
Language:	English
Published:	2003

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