Ion channels in genetic and acquired forms of epilepsy.
Genetic mutations causing dysfunction of both voltage- and ligand-gated ion channels make a major contribution to the cause of many different types of familial epilepsy. Key mechanisms comprise defective Na(+) channels of inhibitory neurons, or GABA(A) receptors affecting pre- or postsynaptic GABAer...
Main Authors: | Lerche, H, Shah, M, Beck, H, Noebels, J, Johnston, D, Vincent, A |
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Format: | Journal article |
Language: | English |
Published: |
2013
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