Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12
Background: Hyperlactataemia is often associated with a poor outcome in severe malaria in African children. To unravel the complex pathophysiology of this condition the relationship between plasma lactate levels, parasite density, pro- and anti-inflammatory cytokines, and haemozoin-containing leucoc...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
BioMed Central
2006
|
| Subjects: |
| _version_ | 1797077827100606464 |
|---|---|
| author | Casals-Pascual, C Kai, O Lowe, B English, M Williams, T Maitland, K Newton, C Peshu, N Roberts, D |
| author_facet | Casals-Pascual, C Kai, O Lowe, B English, M Williams, T Maitland, K Newton, C Peshu, N Roberts, D |
| author_sort | Casals-Pascual, C |
| collection | OXFORD |
| description | Background: Hyperlactataemia is often associated with a poor outcome in severe malaria in African children. To unravel the complex pathophysiology of this condition the relationship between plasma lactate levels, parasite density, pro- and anti-inflammatory cytokines, and haemozoin-containing leucocytes was studied in children with severe falciparum malarial anaemia. Methods: Twenty-six children with a primary diagnosis of severe malarial anaemia with any asexual <em>Plasmodium falciparum</em> parasite density and Hb < 5 g/dL were studied and the association of plasma lactate levels and haemozoin-containing leucocytes, parasite density, pro- and anti-inflammatory cytokines was measured. The same associations were measured in non-severe malaria controls (N=60). Results: Parasite density was associated with lactate levels on admission (r = 0.56, P < 0.005). Moreover, haemozoin-containing neutrophils and IL-12 were strongly associated with plasma lactate levels, independently of parasite density (r = 0.60, P = 0.003 and r = -0.46, P = 0.02, respectively). These associations were not found in controls with uncomplicated malarial anaemia. Conclusion: These data suggest that blood stage parasites, haemozoin and low levels of IL-12 may be associated with the development of hyperlactataemia in severe malaria anaemia. |
| first_indexed | 2024-03-07T00:23:36Z |
| format | Journal article |
| id | oxford-uuid:7d5c724a-4767-4e24-91be-468e0be6722b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:23:36Z |
| publishDate | 2006 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:7d5c724a-4767-4e24-91be-468e0be6722b2022-03-26T21:03:13ZLactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7d5c724a-4767-4e24-91be-468e0be6722bMedical sciencesClinical laboratory sciencesPaediatricsMalariaTropical medicineEnglishOxford University Research Archive - ValetBioMed Central2006Casals-Pascual, CKai, OLowe, BEnglish, MWilliams, TMaitland, KNewton, CPeshu, NRoberts, DBackground: Hyperlactataemia is often associated with a poor outcome in severe malaria in African children. To unravel the complex pathophysiology of this condition the relationship between plasma lactate levels, parasite density, pro- and anti-inflammatory cytokines, and haemozoin-containing leucocytes was studied in children with severe falciparum malarial anaemia. Methods: Twenty-six children with a primary diagnosis of severe malarial anaemia with any asexual <em>Plasmodium falciparum</em> parasite density and Hb < 5 g/dL were studied and the association of plasma lactate levels and haemozoin-containing leucocytes, parasite density, pro- and anti-inflammatory cytokines was measured. The same associations were measured in non-severe malaria controls (N=60). Results: Parasite density was associated with lactate levels on admission (r = 0.56, P < 0.005). Moreover, haemozoin-containing neutrophils and IL-12 were strongly associated with plasma lactate levels, independently of parasite density (r = 0.60, P = 0.003 and r = -0.46, P = 0.02, respectively). These associations were not found in controls with uncomplicated malarial anaemia. Conclusion: These data suggest that blood stage parasites, haemozoin and low levels of IL-12 may be associated with the development of hyperlactataemia in severe malaria anaemia. |
| spellingShingle | Medical sciences Clinical laboratory sciences Paediatrics Malaria Tropical medicine Casals-Pascual, C Kai, O Lowe, B English, M Williams, T Maitland, K Newton, C Peshu, N Roberts, D Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12 |
| title | Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12 |
| title_full | Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12 |
| title_fullStr | Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12 |
| title_full_unstemmed | Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12 |
| title_short | Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12 |
| title_sort | lactate levels in severe malarial anaemia are associated with haemozoin containing neutrophils and low levels of il 12 |
| topic | Medical sciences Clinical laboratory sciences Paediatrics Malaria Tropical medicine |
| work_keys_str_mv | AT casalspascualc lactatelevelsinseveremalarialanaemiaareassociatedwithhaemozoincontainingneutrophilsandlowlevelsofil12 AT kaio lactatelevelsinseveremalarialanaemiaareassociatedwithhaemozoincontainingneutrophilsandlowlevelsofil12 AT loweb lactatelevelsinseveremalarialanaemiaareassociatedwithhaemozoincontainingneutrophilsandlowlevelsofil12 AT englishm lactatelevelsinseveremalarialanaemiaareassociatedwithhaemozoincontainingneutrophilsandlowlevelsofil12 AT williamst lactatelevelsinseveremalarialanaemiaareassociatedwithhaemozoincontainingneutrophilsandlowlevelsofil12 AT maitlandk lactatelevelsinseveremalarialanaemiaareassociatedwithhaemozoincontainingneutrophilsandlowlevelsofil12 AT newtonc lactatelevelsinseveremalarialanaemiaareassociatedwithhaemozoincontainingneutrophilsandlowlevelsofil12 AT peshun lactatelevelsinseveremalarialanaemiaareassociatedwithhaemozoincontainingneutrophilsandlowlevelsofil12 AT robertsd lactatelevelsinseveremalarialanaemiaareassociatedwithhaemozoincontainingneutrophilsandlowlevelsofil12 |