Appraisal of patient-level health economic models of severe mental illness: systematic review
<p><strong>Background</strong></p> Healthcare decision makers require accurate long-term economic models to evaluate the cost-effectiveness of new mental health interventions. <p><strong>Aims</strong></p> To assess the suitability of current patient-l...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Cambridge University Press
2021
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| _version_ | 1826281097989718016 |
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| author | Altunkaya, J Lee, J-S Tsiachristas, A Waite, F Freeman, D Leal, J |
| author_facet | Altunkaya, J Lee, J-S Tsiachristas, A Waite, F Freeman, D Leal, J |
| author_sort | Altunkaya, J |
| collection | OXFORD |
| description | <p><strong>Background</strong></p>
Healthcare decision makers require accurate long-term economic models to evaluate the cost-effectiveness of new mental health interventions.
<p><strong>Aims</strong></p>
To assess the suitability of current patient-level economic models to estimate long-term economic outcomes in severe mental illness.
<p><strong>Method</strong></p>
We undertook pre-specified systematic searches in MEDLINE, Embase and PsycINFO to identify reviews and stand-alone publications of economic models of interventions for schizophrenia, bipolar disorder and major depressive disorder (PROSPERO: CRD42020158243). We screened paper titles and abstracts to identify unique patient-level economic models. We conducted a structured extraction of identified models, recording the presence of key predefined model features. Model quality and validation were appraised using the 2014 ISPOR and 2016 AdViSHE model checklists.
<p><strong>Results</strong></p>
We identified 15 unique patient-level models for psychosis and major depressive disorder from 1481 non-duplicate records. Models addressed schizophrenia (n = 6), bipolar disorder (n = 2) and major depressive disorder (n = 7). The predominant model type was discrete event simulation (n = 9). Model complexity and incorporation of patient heterogeneity varied considerably, and only five models extrapolated costs and outcomes over a lifetime horizon. Key model parameters were often based on low-quality evidence, and checklist quality assessment revealed weak model verification procedures.
<p><strong>Conclusions</strong></p>
Existing patient-level economic models of interventions for severe mental illness have considerable limitations. New modelling efforts must be supplemented by the generation of good-quality, contemporary evidence suitable for model building. Combined effort across the research community is required to build and validate economic extrapolation models suitable for accurately assessing the long-term value of new interventions from short-term clinical trial data. |
| first_indexed | 2024-03-07T00:23:40Z |
| format | Journal article |
| id | oxford-uuid:7d651100-1e41-462e-bd97-13c912b97bcc |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:23:40Z |
| publishDate | 2021 |
| publisher | Cambridge University Press |
| record_format | dspace |
| spelling | oxford-uuid:7d651100-1e41-462e-bd97-13c912b97bcc2022-03-26T21:03:22ZAppraisal of patient-level health economic models of severe mental illness: systematic reviewJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7d651100-1e41-462e-bd97-13c912b97bccEnglishSymplectic ElementsCambridge University Press2021Altunkaya, JLee, J-STsiachristas, AWaite, FFreeman, DLeal, J<p><strong>Background</strong></p> Healthcare decision makers require accurate long-term economic models to evaluate the cost-effectiveness of new mental health interventions. <p><strong>Aims</strong></p> To assess the suitability of current patient-level economic models to estimate long-term economic outcomes in severe mental illness. <p><strong>Method</strong></p> We undertook pre-specified systematic searches in MEDLINE, Embase and PsycINFO to identify reviews and stand-alone publications of economic models of interventions for schizophrenia, bipolar disorder and major depressive disorder (PROSPERO: CRD42020158243). We screened paper titles and abstracts to identify unique patient-level economic models. We conducted a structured extraction of identified models, recording the presence of key predefined model features. Model quality and validation were appraised using the 2014 ISPOR and 2016 AdViSHE model checklists. <p><strong>Results</strong></p> We identified 15 unique patient-level models for psychosis and major depressive disorder from 1481 non-duplicate records. Models addressed schizophrenia (n = 6), bipolar disorder (n = 2) and major depressive disorder (n = 7). The predominant model type was discrete event simulation (n = 9). Model complexity and incorporation of patient heterogeneity varied considerably, and only five models extrapolated costs and outcomes over a lifetime horizon. Key model parameters were often based on low-quality evidence, and checklist quality assessment revealed weak model verification procedures. <p><strong>Conclusions</strong></p> Existing patient-level economic models of interventions for severe mental illness have considerable limitations. New modelling efforts must be supplemented by the generation of good-quality, contemporary evidence suitable for model building. Combined effort across the research community is required to build and validate economic extrapolation models suitable for accurately assessing the long-term value of new interventions from short-term clinical trial data. |
| spellingShingle | Altunkaya, J Lee, J-S Tsiachristas, A Waite, F Freeman, D Leal, J Appraisal of patient-level health economic models of severe mental illness: systematic review |
| title | Appraisal of patient-level health economic models of severe mental illness: systematic review |
| title_full | Appraisal of patient-level health economic models of severe mental illness: systematic review |
| title_fullStr | Appraisal of patient-level health economic models of severe mental illness: systematic review |
| title_full_unstemmed | Appraisal of patient-level health economic models of severe mental illness: systematic review |
| title_short | Appraisal of patient-level health economic models of severe mental illness: systematic review |
| title_sort | appraisal of patient level health economic models of severe mental illness systematic review |
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