The role of the transcription factor BRN2 in melanoma

The role of the transcription factor BRN2 in melanoma

<p>Expression of the POU-domain transcription factor BRN2 is crucial for the developing brain and drives proliferation and invasiveness in cancers of neural crest origin including melanoma. However, our understanding of BRN2 function and how its behaviour is modulated remains incomplete. We th...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Herbert, K
Awduron Eraill:	Goding, C
Fformat:	Traethawd Ymchwil
Cyhoeddwyd:	2018

Eitemau Tebyg

The Brn-2 transcription factor links activated BRAF to melanoma proliferation.
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Targeting Neuronal Transcription Factor BRN2 in Neuroendocrine Tumors
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The POU domain transcription factor Brn-2: elevated expression in malignant melanoma and regulation of melanocyte-specific gene expression.
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Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells.
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BRN2 is a non-canonical melanoma tumor-suppressor
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The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival
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Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion
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Cyhoeddwyd: (2024-09-01)

Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin.
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Brn2 is a transcription factor regulating keratinocyte differentiation with a possible role in the pathogenesis of lichen planus.
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Transcription factors Brn-3α and TRIM16 in cancers, association with hormone reception
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BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma
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NFIB Mediates BRN2 Driven Melanoma Cell Migration and Invasion Through Regulation of EZH2 and MITF
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Reciprocal regulation of BRN2 and NOTCH1/2 signaling synergistically drives melanoma cell migration and invasion
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Runx3, Brn3a and Isl1 interplay orchestrates the transcriptional program in the early stages of proprioceptive neuron development.
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Crystal structure of 5-bromopyrimidine, C4H3BrN2
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Rb induces a proliferative arrest and curtails <it>Brn-2 </it>expression in retinoblastoma cells
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Vascular dysfunction caused by loss of Brn-3b/POU4F2 transcription factor in aortic vascular smooth muscle cells is linked to deregulation of calcium signalling pathways
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Phosphorylation of BRN2 modulates its interaction with the Pax3 promoter to control melanocyte migration and proliferation.
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Crystal structure of 2-bromobenzoic acid hydrazide, C7H7BrN2O
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Crystal structure of N'-(5-bromo-2-hydroxy-3-methoxybenzylidene)-2- methoxybenzohydrazide monohydrate, C16H15BrN2O4·H2O, C16H17BrN2O5
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Impact of Gender in Renal Cell Carcinoma: The Relationship of FABP7 and BRN2 Expression with Overall Survival
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Crystal structure of 3-(2-bromophenyl)-1,1-dimethylthiourea, C9H11BrN2S
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ZEB1 transcription factor promotes immune escape in melanoma
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Transcription regulation in melanocytes and melanoma
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Transcriptional control of phenotype in melanoma
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Cyhoeddwyd: (2019)

Lama2 And Samsn1 Mediate the Effects of Brn4 on Hippocampal Neural Stem Cell Proliferation and Differentiation
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Cyhoeddwyd: (2023-01-01)

ClBRN1 from Chrysanthemum lavandulifolium enhances the stress resistance of transgenic Arabidopsis
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Crystal structure of N'-(5-bromo-2-hydroxy-3-methoxybenzylidene)-4- nitrobenzohydrazide monohydrate, C15H12BrN3O5·H2O, C15H14BrN3O6
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Crystal structure of N-(4-bromophenyl)-4-nitrobenzeneamine, C12H9BrN2O2
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Cyhoeddwyd: (2010-09-01)