Human tumour clonality assessment--flawed but necessary.

Human tumour clonality assessment--flawed but necessary.

One of the premises of the somatic mutation theory of carcinogenesis is that tumours are clonal lesions derived from a single mutated stem cell progenitor. This theory spawned a proliferation of clonality studies, using a variety of different molecular markers to try to determine tumour clonality in...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Leedham, S, Wright, N
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2008

Eitemau Tebyg

The clonal origin of human tumours: is familial adenomatous polyposis (FAP) different?
gan: Leedham, S, et al.
Cyhoeddwyd: (2006)

Methylation and Clonality of Human Colonic Crypts
gan: Graham, T, et al.
Cyhoeddwyd: (2009)

Mapping clonality in individual glands in human Barrett's esophagus
gan: Leedham, S, et al.
Cyhoeddwyd: (2007)

Mapping clonality in individual glands from human Barrett's oesophagus
gan: Leedham, S, et al.
Cyhoeddwyd: (2007)

Patch size in the human colon confounds the assessment of tumour clonality using X chromosome-linked markers
gan: Novelli, M, et al.
Cyhoeddwyd: (2002)

Patch size in the human colon confounds the assessment of tumour clonality using X chromosome-linked markers.
gan: Novelli, M, et al.
Cyhoeddwyd: (2002)

Expansion of a mutated clone: from stem cell to tumour.
gan: Leedham, S, et al.
Cyhoeddwyd: (2008)

The Clonal Origins of Dysplasia from Metaplasia in the Human Stomach
gan: Gutierrez, L, et al.
Cyhoeddwyd: (2009)

The evidence base of proton pump inhibitor chemopreventative agents in Barrett's esophagus--the good, the bad, and the flawed!
gan: Leedham, S, et al.
Cyhoeddwyd: (2007)

Using somatic APC mutations as clonal markers in colonic polyps
gan: Leedham, S, et al.
Cyhoeddwyd: (2007)

Clonal expansion in the human gut: mitochondrial DNA mutations show us the way.
gan: McDonald, SA, et al.
Cyhoeddwyd: (2006)

Monoclonal conversion in human gastric glands gives insights into stem cell and clonal architecture
gan: McDonald, S, et al.
Cyhoeddwyd: (2005)

Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas.
gan: Thirlwell, C, et al.
Cyhoeddwyd: (2010)

Using somatic APC mutations as clonal markers to demonstrate polyclonality in colonic polyps
gan: Leedham, S, et al.
Cyhoeddwyd: (2007)

Clonality, founder mutations, and field cancerization in human ulcerative colitis-associated neoplasia.
gan: Leedham, S, et al.
Cyhoeddwyd: (2009)

The fixation of mutations and clonal expansion in intestinal metaplasia: Field cancerisation in the human stomach
gan: McDonald, S, et al.
Cyhoeddwyd: (2008)

FLAWED /
gan: Ahern, Cecelia, 1981-, author 319498
Cyhoeddwyd: (2016)

Noise: A Flaw in Human Judgment
gan: Umar Sadeeq
Cyhoeddwyd: (2023-06-01)

Noise: A Flaw in Human Judgement /
gan: Daniel, Kahneman, author, et al.
Cyhoeddwyd: (2021)

THE CLONAL PROGRESSION OF BARRETT'S OESOPHAGUS TO OESOPHAGEAL ADENOCARCINOMA
gan: Khan, S, et al.
Cyhoeddwyd: (2012)

Clonal diversification and histogenesis of malignant germ cell tumours
gan: Thomas R. W. Oliver, et al.
Cyhoeddwyd: (2022-08-01)

METHODS FOR TRACING CRYPT STEM CELLS ANCESTRY AND CLONAL ARCHITECTURE USING CPG ISLAND METHYLATION AND MITOCHONDRIAL DNA MUTATIONS
gan: Graham, T, et al.
Cyhoeddwyd: (2009)

Perfect IMPERFECTIONS : HONOURING FLAWS AS HUMAN NATURE /
gan: Ummu Ahmadain, author 655822
Cyhoeddwyd: (2024)

The clonal origins of dysplasia from intestinal metaplasia in the human stomach.
gan: Gutierrez-Gonzalez, L, et al.
Cyhoeddwyd: (2011)

From gene mutations to tumours--stem cells in gastrointestinal carcinogenesis.
gan: Leedham, S, et al.
Cyhoeddwyd: (2005)

SSL-TLS security flaws : the CRIME compression attack security flaws
gan: Peh, Kenneth Hong Wei
Cyhoeddwyd: (2020)

HUMAN SMALL INTESTINAL CRYPTS ARE CLONAL, CONTAIN MULTIPLE STEM CELLS AND MUTATED CRYPTS DIVIDE BY FISSION
gan: Gutierrez-Gonzalez, L, et al.
Cyhoeddwyd: (2009)

When, why and how tumour clonal diversity predicts survival
gan: Robert Noble, et al.
Cyhoeddwyd: (2020-08-01)

Mesenchymal/stromal stem cells: necessary factors in tumour progression
gan: Xinyu Li, et al.
Cyhoeddwyd: (2022-07-01)

Transducers for ultrasonic flaw detection /
gan: 193444 Bindal, V. N.
Cyhoeddwyd: (1999)

Common Flaws in Running Human Evaluation Experiments in NLP
gan: Craig Thomson, et al.
Cyhoeddwyd: (2024-07-01)

Flawed validation of FRAX
gan: Collins, G, et al.
Cyhoeddwyd: (2016)

A flawed trial
gan: Abd Razak, Dzulkifli
Cyhoeddwyd: (2007)

Flaws of the individual or the system?
gan: Haleem, Irm
Cyhoeddwyd: (2020)

Textual and language flaws
gan: Isabel Kareli León Pérez, et al.
Cyhoeddwyd: (2006-01-01)

Flaw growth and fracture
gan: National Symposium on Fracture Mechanics (10th : 1976 : Philadelphia, Pa.), et al.
Cyhoeddwyd: (1977)

Flawed assets clauses
gan: Gullifer, L
Cyhoeddwyd: (2017)

Penetrant flaw detection
gan: 8096 British Standards Institution
Cyhoeddwyd: (1984)

Flawed analysis of an intentional human dosing study and its impact on chlorpyrifos risk assessments
gan: Lianne Sheppard, et al.
Cyhoeddwyd: (2020-10-01)

Fracture toughness, surface flaw sizes and flaw densities in Al2O3
gan: Franco, A, et al.
Cyhoeddwyd: (1997)