Human tumour clonality assessment--flawed but necessary.
One of the premises of the somatic mutation theory of carcinogenesis is that tumours are clonal lesions derived from a single mutated stem cell progenitor. This theory spawned a proliferation of clonality studies, using a variety of different molecular markers to try to determine tumour clonality in...
Autori principali: | Leedham, S, Wright, N |
---|---|
Natura: | Journal article |
Lingua: | English |
Pubblicazione: |
2008
|
Documenti analoghi
-
The clonal origin of human tumours: is familial adenomatous polyposis (FAP) different?
di: Leedham, S, et al.
Pubblicazione: (2006) -
Methylation and Clonality of Human Colonic Crypts
di: Graham, T, et al.
Pubblicazione: (2009) -
Mapping clonality in individual glands in human Barrett's esophagus
di: Leedham, S, et al.
Pubblicazione: (2007) -
Mapping clonality in individual glands from human Barrett's oesophagus
di: Leedham, S, et al.
Pubblicazione: (2007) -
Patch size in the human colon confounds the assessment of tumour clonality using X chromosome-linked markers
di: Novelli, M, et al.
Pubblicazione: (2002)