The use of pre- pro- and synbiotics in adult intensive care unit patients: systematic review.
BACKGROUND and AIMS: This review investigated whether the administration of enteral pre-, pro- and synbiotics compared with controls in adult intensive care unit (ICU) patients reduced the incidence of nosocomial infections, length of ICU stay, hospital mortality and specifically pneumonia. METHODS...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2007
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| _version_ | 1826281125248499712 |
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| author | Watkinson, P Barber, V Dark, P Young, J |
| author_facet | Watkinson, P Barber, V Dark, P Young, J |
| author_sort | Watkinson, P |
| collection | OXFORD |
| description | BACKGROUND and AIMS: This review investigated whether the administration of enteral pre-, pro- and synbiotics compared with controls in adult intensive care unit (ICU) patients reduced the incidence of nosocomial infections, length of ICU stay, hospital mortality and specifically pneumonia. METHODS: Systematic review of randomised controlled trials comparing enteral feeding and pre-, pro- or synbiotics, versus standard enteral feed alone, in patients admitted to adult ICUs. RESULTS: Eight randomised studies with a total of 999 critically ill adult patients met the inclusion criteria. Pre- pro- or synbiotics were not associated with any significant change in the outcomes studied-length of ICU stay, hospital mortality and the incidence of nosocomial infection and more specifically pneumonia incidence. Few data were available for other outcomes. CONCLUSIONS: The use of pre- pro- or synbiotics in adult critically ill patients confers no statistically significant benefit in the outcome criteria studied. There is currently a lack of evidence to support the use of pre- pro- or synbiotics in patients admitted to adult ICUs, and a large well-designed trial is needed in this area. |
| first_indexed | 2024-03-07T00:24:05Z |
| format | Journal article |
| id | oxford-uuid:7d85aa38-acf8-4e91-8d1b-562b02b6dd40 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:24:05Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:7d85aa38-acf8-4e91-8d1b-562b02b6dd402022-03-26T21:04:11ZThe use of pre- pro- and synbiotics in adult intensive care unit patients: systematic review.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7d85aa38-acf8-4e91-8d1b-562b02b6dd40EnglishSymplectic Elements at Oxford2007Watkinson, PBarber, VDark, PYoung, J BACKGROUND and AIMS: This review investigated whether the administration of enteral pre-, pro- and synbiotics compared with controls in adult intensive care unit (ICU) patients reduced the incidence of nosocomial infections, length of ICU stay, hospital mortality and specifically pneumonia. METHODS: Systematic review of randomised controlled trials comparing enteral feeding and pre-, pro- or synbiotics, versus standard enteral feed alone, in patients admitted to adult ICUs. RESULTS: Eight randomised studies with a total of 999 critically ill adult patients met the inclusion criteria. Pre- pro- or synbiotics were not associated with any significant change in the outcomes studied-length of ICU stay, hospital mortality and the incidence of nosocomial infection and more specifically pneumonia incidence. Few data were available for other outcomes. CONCLUSIONS: The use of pre- pro- or synbiotics in adult critically ill patients confers no statistically significant benefit in the outcome criteria studied. There is currently a lack of evidence to support the use of pre- pro- or synbiotics in patients admitted to adult ICUs, and a large well-designed trial is needed in this area. |
| spellingShingle | Watkinson, P Barber, V Dark, P Young, J The use of pre- pro- and synbiotics in adult intensive care unit patients: systematic review. |
| title | The use of pre- pro- and synbiotics in adult intensive care unit patients: systematic review. |
| title_full | The use of pre- pro- and synbiotics in adult intensive care unit patients: systematic review. |
| title_fullStr | The use of pre- pro- and synbiotics in adult intensive care unit patients: systematic review. |
| title_full_unstemmed | The use of pre- pro- and synbiotics in adult intensive care unit patients: systematic review. |
| title_short | The use of pre- pro- and synbiotics in adult intensive care unit patients: systematic review. |
| title_sort | use of pre pro and synbiotics in adult intensive care unit patients systematic review |
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