The role of biomarkers for the diagnosis of implant-related infections in orthopaedics and trauma
Diagnosis of implant-related (periprosthetic joint) infections poses a major challenge to infection disease physicians and orthopaedic surgeons. Conventional diagnostic tests continue to suffer from issues of accuracy and feasibility. Biomarkers are used throughout medicine for diagnostic and progno...
| Main Authors: | , , |
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| Format: | Book section |
| Language: | English |
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Springer, Cham
2017
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| _version_ | 1826281125639618560 |
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| author | Alvand, A Rezapoor, M Parvizi, J |
| author_facet | Alvand, A Rezapoor, M Parvizi, J |
| author_sort | Alvand, A |
| collection | OXFORD |
| description | Diagnosis of implant-related (periprosthetic joint) infections poses a major challenge to infection disease physicians and orthopaedic surgeons. Conventional diagnostic tests continue to suffer from issues of accuracy and feasibility. Biomarkers are used throughout medicine for diagnostic and prognostic purposes, as they are able to objectively determine the presence of a disease or a biological state. There is increasing evidence to support the measurement of specific biomarkers in serum and/or synovial fluid of patients with suspected periprosthetic joint infections. Promising serum biomarkers include interleukin (IL)-4, IL-6, tumour necrosis factor (TNF)-α, procalcitonin, soluble intercellular adhesion molecule 1 (sICAM-1), and D-dimer. In addition to c-reactive protein and leucocyte esterase, promising biomarkers that can be measured in synovial fluid include antimicrobial proteins such as human β-defensin (HBD)-2 and human β-defensin (HBD)-3, and cathelicidin LL-37, as well as several interleukins such as IL-1β, IL-6, IL-8, IL-17, TNF- α, interferon-δ, and vascular endothelial growth factor. |
| first_indexed | 2024-03-07T00:24:06Z |
| format | Book section |
| id | oxford-uuid:7d86a5e9-6a74-4c49-a66c-0f12607d7598 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:24:06Z |
| publishDate | 2017 |
| publisher | Springer, Cham |
| record_format | dspace |
| spelling | oxford-uuid:7d86a5e9-6a74-4c49-a66c-0f12607d75982022-03-26T21:04:12ZThe role of biomarkers for the diagnosis of implant-related infections in orthopaedics and traumaBook sectionhttp://purl.org/coar/resource_type/c_3248uuid:7d86a5e9-6a74-4c49-a66c-0f12607d7598EnglishSymplectic Elements at OxfordSpringer, Cham2017Alvand, ARezapoor, MParvizi, JDiagnosis of implant-related (periprosthetic joint) infections poses a major challenge to infection disease physicians and orthopaedic surgeons. Conventional diagnostic tests continue to suffer from issues of accuracy and feasibility. Biomarkers are used throughout medicine for diagnostic and prognostic purposes, as they are able to objectively determine the presence of a disease or a biological state. There is increasing evidence to support the measurement of specific biomarkers in serum and/or synovial fluid of patients with suspected periprosthetic joint infections. Promising serum biomarkers include interleukin (IL)-4, IL-6, tumour necrosis factor (TNF)-α, procalcitonin, soluble intercellular adhesion molecule 1 (sICAM-1), and D-dimer. In addition to c-reactive protein and leucocyte esterase, promising biomarkers that can be measured in synovial fluid include antimicrobial proteins such as human β-defensin (HBD)-2 and human β-defensin (HBD)-3, and cathelicidin LL-37, as well as several interleukins such as IL-1β, IL-6, IL-8, IL-17, TNF- α, interferon-δ, and vascular endothelial growth factor. |
| spellingShingle | Alvand, A Rezapoor, M Parvizi, J The role of biomarkers for the diagnosis of implant-related infections in orthopaedics and trauma |
| title | The role of biomarkers for the diagnosis of implant-related infections in orthopaedics and trauma |
| title_full | The role of biomarkers for the diagnosis of implant-related infections in orthopaedics and trauma |
| title_fullStr | The role of biomarkers for the diagnosis of implant-related infections in orthopaedics and trauma |
| title_full_unstemmed | The role of biomarkers for the diagnosis of implant-related infections in orthopaedics and trauma |
| title_short | The role of biomarkers for the diagnosis of implant-related infections in orthopaedics and trauma |
| title_sort | role of biomarkers for the diagnosis of implant related infections in orthopaedics and trauma |
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