A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.

A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.

Type 2 innate lymphoid cells (ILC2s, nuocytes, NHC) require RORA and GATA3 for their development. We show that human ILC2s express skin homing receptors and infiltrate the skin after allergen challenge, where they produce the type 2 cytokines IL-5 and IL-13. Skin-derived ILC2s express the IL-33 rece...

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Бібліографічні деталі
Автори: Salimi, M, Barlow, J, Saunders, S, Xue, L, Gutowska-Owsiak, D, Wang, X, Huang, L, Johnson, D, Scanlon, S, McKenzie, A, Fallon, P, Ogg, G
Формат: Journal article
Мова:English
Опубліковано: Rockefeller University Press. 2013

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