Active suppression induced by anti-CD4.
Treatment with a non-depleting monoclonal antibody to CD4 in the presence of mouse thyroglobulin (MTg) inhibits the development of murine autoimmune thyroiditis. This unresponsiveness was transferrable since such treatment generated a population of donor cells which could suppress the thyroiditis in...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1993
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| _version_ | 1797077887532138496 |
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| author | Hutchings, P Cooke, A Dawe, K Waldmann, H Roitt, I |
| author_facet | Hutchings, P Cooke, A Dawe, K Waldmann, H Roitt, I |
| author_sort | Hutchings, P |
| collection | OXFORD |
| description | Treatment with a non-depleting monoclonal antibody to CD4 in the presence of mouse thyroglobulin (MTg) inhibits the development of murine autoimmune thyroiditis. This unresponsiveness was transferrable since such treatment generated a population of donor cells which could suppress the thyroiditis induced in lightly irradiated recipients by subsequent challenge with specific antigen. The suppression appears to be both antigen specific and antigen dependent and seems to discriminate between TH1 and TH2 helper subsets in that there is no significant effect on anti-MTg autoantibodies after challenge. |
| first_indexed | 2024-03-07T00:24:29Z |
| format | Journal article |
| id | oxford-uuid:7da8acc7-898a-4932-a926-d4fdfd7beb79 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:24:29Z |
| publishDate | 1993 |
| record_format | dspace |
| spelling | oxford-uuid:7da8acc7-898a-4932-a926-d4fdfd7beb792022-03-26T21:05:03ZActive suppression induced by anti-CD4.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7da8acc7-898a-4932-a926-d4fdfd7beb79EnglishSymplectic Elements at Oxford1993Hutchings, PCooke, ADawe, KWaldmann, HRoitt, ITreatment with a non-depleting monoclonal antibody to CD4 in the presence of mouse thyroglobulin (MTg) inhibits the development of murine autoimmune thyroiditis. This unresponsiveness was transferrable since such treatment generated a population of donor cells which could suppress the thyroiditis induced in lightly irradiated recipients by subsequent challenge with specific antigen. The suppression appears to be both antigen specific and antigen dependent and seems to discriminate between TH1 and TH2 helper subsets in that there is no significant effect on anti-MTg autoantibodies after challenge. |
| spellingShingle | Hutchings, P Cooke, A Dawe, K Waldmann, H Roitt, I Active suppression induced by anti-CD4. |
| title | Active suppression induced by anti-CD4. |
| title_full | Active suppression induced by anti-CD4. |
| title_fullStr | Active suppression induced by anti-CD4. |
| title_full_unstemmed | Active suppression induced by anti-CD4. |
| title_short | Active suppression induced by anti-CD4. |
| title_sort | active suppression induced by anti cd4 |
| work_keys_str_mv | AT hutchingsp activesuppressioninducedbyanticd4 AT cookea activesuppressioninducedbyanticd4 AT dawek activesuppressioninducedbyanticd4 AT waldmannh activesuppressioninducedbyanticd4 AT roitti activesuppressioninducedbyanticd4 |