A cycloaddition-rearrangement approach to the squalestatins

A cycloaddition-rearrangement approach to the squalestatins

Reaction of diazodiketoester 4 with methyl glyoxylate in toluene in the presence of catalytic rhodium(II) acetate generates the 6,8- dioxabicyclo[3.2.1]octane 5 as a single regio- and stereo-isomer in good yield. Elaboration provides a suitable alcohol 7 for acid-catalysed rearrangement to give the...

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Bibliografiske detaljer
Main Authors:	Hodgson, D, Bailey, J, Harrison, T
Format:	Journal article
Udgivet:	1996

Lignende værker

Evolution of a cycloaddition-rearrangement approach to the squalestatins: a quarter-century odyssey
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