A cycloaddition-rearrangement approach to the squalestatins
Reaction of diazodiketoester 4 with methyl glyoxylate in toluene in the presence of catalytic rhodium(II) acetate generates the 6,8- dioxabicyclo[3.2.1]octane 5 as a single regio- and stereo-isomer in good yield. Elaboration provides a suitable alcohol 7 for acid-catalysed rearrangement to give the...
| Hlavní autoři: | , , |
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| Médium: | Journal article |
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1996
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