Androgen generation in adipose tissue in women with simple obesity--a site-specific role for 17beta-hydroxysteroid dehydrogenase type 5.

Androgen generation in adipose tissue in women with simple obesity--a site-specific role for 17beta-hydroxysteroid dehydrogenase type 5.

Women with polycystic ovary syndrome (PCOS) have high circulating androgens, thought to originate from ovaries and adrenals, and frequently suffer from the metabolic syndrome including obesity. However, serum androgens are positively associated with body mass index (BMI) not only in PCOS, but also i...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Quinkler, M, Sinha, B, Tomlinson, J, Bujalska, I, Stewart, P, Arlt, W
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2004

Παρόμοια τεκμήρια

Expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2002)

The role of 11 beta-hydroxysteroid dehydrogenase in central obesity and osteoporosis.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2000)

11 beta-hydroxysteroid dehydrogenase type 1 in obese children
ανά: Wiegand, S, κ.ά.
Έκδοση: (2007)

Expression profiling of 11beta-hydroxysteroid dehydrogenase type-1 and glucocorticoid-target genes in subcutaneous and omental human preadipocytes.
ανά: Bujalska, I, κ.ά.
Έκδοση: (2006)

Reduced 11beta-hydroxysteroid dehydrogenase type 1 activity in obese boys.
ανά: Wiegand, S, κ.ά.
Έκδοση: (2007)

The functional consequences of 11beta-hydroxysteroid dehydrogenase expression in adipose tissue.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2002)

Cortisol, 11 beta-hydroxysteroid dehydrogenase type 1 and central obesity.
ανά: Stewart, P, κ.ά.
Έκδοση: (2002)

Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2001)

Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2001)

Characterisation of 11beta-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat.
ανά: Bujalska, I, κ.ά.
Έκδοση: (2007)

The role of 11beta-hydroxysteroid dehydrogenase 1 in adipogenesis in thyroid-associated ophthalmopathy.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2010)

Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1.
ανά: Bujalska, I, κ.ά.
Έκδοση: (2005)

11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol.
ανά: Bujalska, I, κ.ά.
Έκδοση: (2002)

Structure and function of human 17beta-hydroxysteroid dehydrogenases.
ανά: Lukacik, P, κ.ά.
Έκδοση: (2006)

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2004)

Weight loss increases 11beta-hydroxysteroid dehydrogenase type 1 expression in human adipose tissue.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2004)

A novel selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis.
ανά: Bujalska, I, κ.ά.
Έκδοση: (2008)

Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency.
ανά: Draper, N, κ.ά.
Έκδοση: (2003)

Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2003)

Active site directed mutagenesis of 3 beta/17 beta-hydroxysteroid dehydrogenase establishes differential effects on short-chain dehydrogenase/reductase reactions.
ανά: Oppermann, U, κ.ά.
Έκδοση: (1997)

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ανά: Jose Antonio Mondragón Dr, κ.ά.
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Corticosteroids, 11beta-hydroxysteroid dehydrogenase isozymes and the rabbit choroid plexus.
ανά: Sinclair, A, κ.ά.
Έκδοση: (2007)

Effects of glucocorticoids on fat mass and the therapeutic potential of targeting II beta-hydroxysteroid dehydrogenase type I in obesity
ανά: Tomlinson, J
Έκδοση: (2009)

Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13
ανά: Shenping Liu, κ.ά.
Έκδοση: (2023-08-01)

11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.
ανά: Morgan, SA, κ.ά.
Έκδοση: (2009)

Cerebrospinal fluid production - A role for 11 beta-hydroxysteroid dehydrogenase type 1?
ανά: Rauz, S, κ.ά.
Έκδοση: (2004)

11beta-hydroxysteroid dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus.
ανά: Valsamakis, G, κ.ά.
Έκδοση: (2004)

11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets.
ανά: Swali, A, κ.ά.
Έκδοση: (2008)

Human type 10 17 beta-hydroxysteroid dehydrogenase: molecular modelling and substrate docking.
ανά: Nordling, E, κ.ά.
Έκδοση: (2001)

Expression of 11 beta-hydroxysteroid dehydrogenase isoenzymes in the human pituitary: induction of the type 2 enzyme in corticotropinomas and other pituitary tumors.
ανά: Korbonits, M, κ.ά.
Έκδοση: (2001)

Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for patients with metabolic syndrome: is the target liver, fat, or both?
ανά: Stewart, P, κ.ά.
Έκδοση: (2009)

Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2005)

Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis.
ανά: Tomlinson, J, κ.ά.
Έκδοση: (2007)

11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes.
ανά: Morgan, SA, κ.ά.
Έκδοση: (2010)

Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type 1 in humans.
ανά: Stimson, R, κ.ά.
Έκδοση: (2009)

11Beta-hydroxysteroid dehydrogenase type 1 in human disease: a novel therapeutic target.
ανά: Tomlinson, J
Έκδοση: (2005)

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ανά: Giridharan Nappan V, κ.ά.
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ανά: Crowley, R, κ.ά.
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