BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions

BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions

The RAS family of proteins is amongst the most highly mutated in human cancers and has so far eluded drug therapy. Currently, much effort is being made to discover mutant RAS inhibitors and in vitro screening for RAS-binding drugs must be followed by cell-based assays. Here, we have developed a robu...

Bibliografski detalji
Glavni autori:	Bery, N, Cruz-Migoni, A, Bataille, C, Quevedo, C, Tulmin, H, Miller, A, Russell, A, Phillips, S, Carr, S, Rabbitts, T
Format:	Journal article
Jezik:	English
Izdano:	eLife Sciences Publications 2018

Slični predmeti

BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions
od: Nicolas Bery, i dr.
Izdano: (2018-07-01)

Correction: BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions
od: Nicolas Bery, i dr.
Izdano: (2018-08-01)

Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment
od: Quevedo, C, i dr.
Izdano: (2018)

Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds
od: Cruz-Migoni, A, i dr.
Izdano: (2019)

Bioluminescence Resonance Energy Transfer 2 (BRET2)‐based RAS biosensors to characterize RAS inhibitors
od: Bery, N, i dr.
Izdano: (2019)

Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment
od: Camilo E. Quevedo, i dr.
Izdano: (2018-08-01)

Interfering with RAS-effector protein interactions prevent RAS-dependent tumour initiation and causes stop-start control of cancer growth.
od: Tanaka, T, i dr.
Izdano: (2010)

Abstract LB-068: From intracellular antibody fragments to small molecule inhibitors of mutant KRAS
od: Quevedo, C, i dr.
Izdano: (2017)

Monoterpene regulation of Ras and Ras-related protein expression
od: Sarah A. Holstein, i dr.
Izdano: (2003-06-01)

Recent Developments in Targeting RAS Downstream Effectors for RAS-Driven Cancer Therapy
od: Ozge Tatli, i dr.
Izdano: (2021-12-01)

The Ins and Outs of RAS Effector Complexes
od: Christina Kiel, i dr.
Izdano: (2021-02-01)

Construction of an Enzymatically-Conjugated DNA Aptamer–Protein Hybrid Molecule for Use as a BRET-Based Biosensor
od: Masayasu Mie, i dr.
Izdano: (2020-10-01)

Intrabodies based on intracellular capture frameworks that bind the RAS protein with high affinity and impair oncogenic transformation.
od: Tanaka, T, i dr.
Izdano: (2003)

Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS.
od: Tanaka, T, i dr.
Izdano: (2007)

Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector.
od: Francis S Willard, i dr.
Izdano: (2009-01-01)

The energetics of nucleotide binding to RAS proteins
od: Worth, G, i dr.
Izdano: (1992)

The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions.
od: Hossein Nakhaeizadeh, i dr.
Izdano: (2016-01-01)

Glycyrrhetinic acid binds to the conserved P-loop region and interferes with the interaction of RAS-effector proteins
od: Yuan Zhang, i dr.
Izdano: (2019-03-01)

SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation
od: Xiaoyu Zhang, i dr.
Izdano: (2017-04-01)

Developments in FRET- and BRET-Based Biosensors
od: Yuexin Wu, i dr.
Izdano: (2022-10-01)

Ras Downstream Effector GGCT Alleviates Oncogenic Stress
od: Zaoke He, i dr.
Izdano: (2019-09-01)

Phospholipase C isozymes as effectors of Ras superfamily GTPases
od: T. Kendall Harden, i dr.
Izdano: (2009-01-01)

Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange
od: Guillard, S, i dr.
Izdano: (2017)

Ras and Ras mutations in cancer
od: Rajasekharan Satish, i dr.
Izdano: (2013-07-01)

A Cell-based Screening Method Using an Intracellular Antibody for Discovering Small Molecules Targeting Hard-to-drug Proteins
od: Nicolas Bery, i dr.
Izdano: (2022-02-01)

Association rate constants of ras-effector interactions are evolutionarily conserved.
od: Christina Kiel, i dr.
Izdano: (2008-12-01)

REGA-SIGN: Development of a Novel Set of NanoBRET-Based G Protein Biosensors
od: Katrijn Boon, i dr.
Izdano: (2023-07-01)

WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation
od: Woo-Jeong Jeong, i dr.
Izdano: (2019-01-01)

Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas
od: Lili Li, i dr.
Izdano: (2019-11-01)

Spent Hen Muscle Protein-Derived RAS Regulating Peptides Show Antioxidant Activity in Vascular Cells
od: Hongbing Fan, i dr.
Izdano: (2021-02-01)

Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange
od: Sandrine Guillard, i dr.
Izdano: (2017-07-01)

Predicted ‘wiring landscape’ of Ras-effector interactions in 29 human tissues
od: Simona Catozzi, i dr.
Izdano: (2021-02-01)

P395: PHARMACEUTICAL TARGETING OF RAS IN ACUTE MYELOID LEUKAEMIA
od: D. Coleman, i dr.
Izdano: (2022-06-01)

BRET biosensor analysis of receptor tyrosine kinase functionality
od: Sana eSiddiqui, i dr.
Izdano: (2013-04-01)

Protein-based Degrader Strategies against Oncogenic RAS
od: Cheah, Keith M.
Izdano: (2023)

Prediction of male fertility using Ras-related proteins
od: Jeong-Won Bae, i dr.
Izdano: (2022-11-01)

Mechanisms of Ras Membrane Organization and Signaling: Ras Rocks Again
od: Daniel Abankwa, i dr.
Izdano: (2020-11-01)

Pan RAS-binding compounds selected from a chemical library by inhibiting interaction between RAS and a reduced affinity intracellular antibody
od: Tomoyuki Tanaka, i dr.
Izdano: (2021-01-01)

An engineered protein antagonist of K-Ras/B-Raf interaction
od: Parker, Jillian A., i dr.
Izdano: (2017)

An engineered protein antagonist of K-Ras/B-Raf interaction
od: Monique J. Kauke, i dr.
Izdano: (2017-07-01)