BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions

BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions

The RAS family of proteins is amongst the most highly mutated in human cancers and has so far eluded drug therapy. Currently, much effort is being made to discover mutant RAS inhibitors and in vitro screening for RAS-binding drugs must be followed by cell-based assays. Here, we have developed a robu...

Полное описание

Библиографические подробности
Главные авторы:	Bery, N, Cruz-Migoni, A, Bataille, C, Quevedo, C, Tulmin, H, Miller, A, Russell, A, Phillips, S, Carr, S, Rabbitts, T
Формат:	Journal article
Язык:	English
Опубликовано:	eLife Sciences Publications 2018

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