Statins bind to cardiac ryanodine receptor (RyR2) channels to alter opening frequency

Eitemau Tebyg

• Atorvastatin activates skeletal RyR1 channels: towards reducing statin side-effects
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  Cyhoeddwyd: (2018)
• Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform
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  Cyhoeddwyd: (2017)
• Voltage-dependent modulation of cardiac ryanodine receptors (RyR2) by protamine.
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  Cyhoeddwyd: (2009-12-01)
• Modelling the ATP binding site of RyR2 to rationalise ligand-induced gating behaviour
  gan: Lindsay, C, et al.
  Cyhoeddwyd: (2019)
• Impaired ligand regulation of native RyR2 channels in the catecholaminergic polymorphic ventricular tachycardia mutation, RyR2-V2475F(+/−)
  gan: Wilson, A, et al.
  Cyhoeddwyd: (2019)