Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells.

Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells.

Pancreatic and colorectal carcinomas frequently express oncogenic/mutant K-Ras that contributes to both tumorigenesis and clinically observed resistance to radiation treatment. We have previously shown that farnesyltransferase inhibitors (FTI) radiosensitize many pancreatic and colorectal cancer cel...

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Bibliographic Details
Main Authors: Cengel, K, Voong, K, Chandrasekaran, S, Maggiorella, L, Brunner, T, Stanbridge, E, Kao, G, Mckenna, W, Bernhard, E
Format: Journal article
Language:English
Published: 2007

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