Does suppression of oscillatory synchronisation mediate some of the therapeutic effects of DBS in patients with Parkinson's disease?
There is growing evidence for exaggerated oscillatory neuronal synchronisation in patients with Parkinson's disease (PD). In particular, oscillations at around 20 Hz, in the so-called beta frequency band, relate to the cardinal symptoms of bradykinesia and rigidity. Deep brain stimulation (DBS)...
| Asıl Yazarlar: | , , |
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| Materyal Türü: | Journal article |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
Frontiers Media
2012
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| _version_ | 1826281226459152384 |
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| author | Eusebio, A Cagnan, H Brown, P |
| author_facet | Eusebio, A Cagnan, H Brown, P |
| author_sort | Eusebio, A |
| collection | OXFORD |
| description | There is growing evidence for exaggerated oscillatory neuronal synchronisation in patients with Parkinson's disease (PD). In particular, oscillations at around 20 Hz, in the so-called beta frequency band, relate to the cardinal symptoms of bradykinesia and rigidity. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) can significantly improve these motor impairments. Recent evidence has demonstrated reduction of beta oscillations concurrent with alleviation of PD motor symptoms, raising the possibility that suppression of aberrant activity may mediate the effects of DBS. Here we review the evidence supporting suppression of pathological oscillations during stimulation and discuss how this might underlie the efficacy of DBS. We also consider how beta activity may provide a feedback signal suitable for next generation closed-loop and intelligent stimulators. |
| first_indexed | 2024-03-07T00:25:37Z |
| format | Journal article |
| id | oxford-uuid:7e07d259-f69b-43c1-9492-94b9326500c6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:25:37Z |
| publishDate | 2012 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | oxford-uuid:7e07d259-f69b-43c1-9492-94b9326500c62022-03-26T21:07:37ZDoes suppression of oscillatory synchronisation mediate some of the therapeutic effects of DBS in patients with Parkinson's disease?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7e07d259-f69b-43c1-9492-94b9326500c6EnglishSymplectic Elements at OxfordFrontiers Media2012Eusebio, ACagnan, HBrown, PThere is growing evidence for exaggerated oscillatory neuronal synchronisation in patients with Parkinson's disease (PD). In particular, oscillations at around 20 Hz, in the so-called beta frequency band, relate to the cardinal symptoms of bradykinesia and rigidity. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) can significantly improve these motor impairments. Recent evidence has demonstrated reduction of beta oscillations concurrent with alleviation of PD motor symptoms, raising the possibility that suppression of aberrant activity may mediate the effects of DBS. Here we review the evidence supporting suppression of pathological oscillations during stimulation and discuss how this might underlie the efficacy of DBS. We also consider how beta activity may provide a feedback signal suitable for next generation closed-loop and intelligent stimulators. |
| spellingShingle | Eusebio, A Cagnan, H Brown, P Does suppression of oscillatory synchronisation mediate some of the therapeutic effects of DBS in patients with Parkinson's disease? |
| title | Does suppression of oscillatory synchronisation mediate some of the therapeutic effects of DBS in patients with Parkinson's disease? |
| title_full | Does suppression of oscillatory synchronisation mediate some of the therapeutic effects of DBS in patients with Parkinson's disease? |
| title_fullStr | Does suppression of oscillatory synchronisation mediate some of the therapeutic effects of DBS in patients with Parkinson's disease? |
| title_full_unstemmed | Does suppression of oscillatory synchronisation mediate some of the therapeutic effects of DBS in patients with Parkinson's disease? |
| title_short | Does suppression of oscillatory synchronisation mediate some of the therapeutic effects of DBS in patients with Parkinson's disease? |
| title_sort | does suppression of oscillatory synchronisation mediate some of the therapeutic effects of dbs in patients with parkinson s disease |
| work_keys_str_mv | AT eusebioa doessuppressionofoscillatorysynchronisationmediatesomeofthetherapeuticeffectsofdbsinpatientswithparkinsonsdisease AT cagnanh doessuppressionofoscillatorysynchronisationmediatesomeofthetherapeuticeffectsofdbsinpatientswithparkinsonsdisease AT brownp doessuppressionofoscillatorysynchronisationmediatesomeofthetherapeuticeffectsofdbsinpatientswithparkinsonsdisease |