The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa

The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa

There is paucity of data regarding the geographical distribution, incidence, and phylogenetics of multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa. Here we present a phylogenetic reconstruction of whole genome sequenced 249 contemporaneous S. Typhi isolated between 2008-2015 in 11 s...

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Bibliografske podrobnosti
Main Authors: Park, SE, Pham, DT, Boinett, C, Wong, VK, Pak, GD, Panzner, U, Espinoza, LMC, Von Kalckreuth, V, Im, J, Schütt-Gerowitt, H, Crump, JA, Breiman, RF, Adu-Sarkodie, Y, Owusu-Dabo, E, Rakotozandrindrainy, R, Soura, AB, Aseffa, A, Gasmelseed, N, Keddy, KH, May, J, Sow, AG, Aaby, P, Biggs, HM, Hertz, JT, Montgomery, JM, Cosmas, L, Olack, B, Fields, B, Sarpong, N, Razafindrabe, TJL, Raminosoa, TM, Kabore, LP, Sampo, E, Teferi, M, Yeshitela, B, Tayeb, MA, Sooka, A, Meyer, CG, Krumkamp, R, Dekker, DM, Jaeger, A, Poppert, S, Tall, A, Niang, A, Bjerregaard-Andersen, M, Løfberg, SV, Seo, HJ, Jeon, HJ, Deerin, JF, Park, J, Konings, F, Ali, M, Clemens, JD, Hughes, P, Sendagala, JN, Vudriko, T, Downing, R, Ikumapayi, UN, Mackenzie, GA, Obaro, S, Argimon, S, Aanensen, DM, Page, A, Keane, JA, Duchene, S, Dyson, Z, Holt, KE, Dougan, G, Marks, F, Baker, S
Format: Journal article
Jezik:English
Izdano: Springer Nature 2018
Opis
Izvleček:There is paucity of data regarding the geographical distribution, incidence, and phylogenetics of multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa. Here we present a phylogenetic reconstruction of whole genome sequenced 249 contemporaneous S. Typhi isolated between 2008-2015 in 11 sub-Saharan African countries, in context of the 2,057 global S. Typhi genomic framework. Despite the broad genetic diversity, the majority of organisms (225/249; 90%) belong to only three genotypes, 4.3.1 (H58) (99/249; 40%), 3.1.1 (97/249; 39%), and 2.3.2 (29/249; 12%). Genotypes 4.3.1 and 3.1.1 are confined within East and West Africa, respectively. MDR phenotype is found in over 50% of organisms restricted within these dominant genotypes. High incidences of MDR S. Typhi are calculated in locations with a high burden of typhoid, specifically in children aged <15 years. Antimicrobial stewardship, MDR surveillance, and the introduction of typhoid conjugate vaccines will be critical for the control of MDR typhoid in Africa.

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