The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa
There is paucity of data regarding the geographical distribution, incidence, and phylogenetics of multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa. Here we present a phylogenetic reconstruction of whole genome sequenced 249 contemporaneous S. Typhi isolated between 2008-2015 in 11 s...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2018
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| _version_ | 1797077965964574720 |
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| author | Park, SE Pham, DT Boinett, C Wong, VK Pak, GD Panzner, U Espinoza, LMC Von Kalckreuth, V Im, J Schütt-Gerowitt, H Crump, JA Breiman, RF Adu-Sarkodie, Y Owusu-Dabo, E Rakotozandrindrainy, R Soura, AB Aseffa, A Gasmelseed, N Keddy, KH May, J Sow, AG Aaby, P Biggs, HM Hertz, JT Montgomery, JM Cosmas, L Olack, B Fields, B Sarpong, N Razafindrabe, TJL Raminosoa, TM Kabore, LP Sampo, E Teferi, M Yeshitela, B Tayeb, MA Sooka, A Meyer, CG Krumkamp, R Dekker, DM Jaeger, A Poppert, S Tall, A Niang, A Bjerregaard-Andersen, M Løfberg, SV Seo, HJ Jeon, HJ Deerin, JF Park, J Konings, F Ali, M Clemens, JD Hughes, P Sendagala, JN Vudriko, T Downing, R Ikumapayi, UN Mackenzie, GA Obaro, S Argimon, S Aanensen, DM Page, A Keane, JA Duchene, S Dyson, Z Holt, KE Dougan, G Marks, F Baker, S |
| author_facet | Park, SE Pham, DT Boinett, C Wong, VK Pak, GD Panzner, U Espinoza, LMC Von Kalckreuth, V Im, J Schütt-Gerowitt, H Crump, JA Breiman, RF Adu-Sarkodie, Y Owusu-Dabo, E Rakotozandrindrainy, R Soura, AB Aseffa, A Gasmelseed, N Keddy, KH May, J Sow, AG Aaby, P Biggs, HM Hertz, JT Montgomery, JM Cosmas, L Olack, B Fields, B Sarpong, N Razafindrabe, TJL Raminosoa, TM Kabore, LP Sampo, E Teferi, M Yeshitela, B Tayeb, MA Sooka, A Meyer, CG Krumkamp, R Dekker, DM Jaeger, A Poppert, S Tall, A Niang, A Bjerregaard-Andersen, M Løfberg, SV Seo, HJ Jeon, HJ Deerin, JF Park, J Konings, F Ali, M Clemens, JD Hughes, P Sendagala, JN Vudriko, T Downing, R Ikumapayi, UN Mackenzie, GA Obaro, S Argimon, S Aanensen, DM Page, A Keane, JA Duchene, S Dyson, Z Holt, KE Dougan, G Marks, F Baker, S |
| author_sort | Park, SE |
| collection | OXFORD |
| description | There is paucity of data regarding the geographical distribution, incidence, and phylogenetics of multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa. Here we present a phylogenetic reconstruction of whole genome sequenced 249 contemporaneous S. Typhi isolated between 2008-2015 in 11 sub-Saharan African countries, in context of the 2,057 global S. Typhi genomic framework. Despite the broad genetic diversity, the majority of organisms (225/249; 90%) belong to only three genotypes, 4.3.1 (H58) (99/249; 40%), 3.1.1 (97/249; 39%), and 2.3.2 (29/249; 12%). Genotypes 4.3.1 and 3.1.1 are confined within East and West Africa, respectively. MDR phenotype is found in over 50% of organisms restricted within these dominant genotypes. High incidences of MDR S. Typhi are calculated in locations with a high burden of typhoid, specifically in children aged <15 years. Antimicrobial stewardship, MDR surveillance, and the introduction of typhoid conjugate vaccines will be critical for the control of MDR typhoid in Africa. |
| first_indexed | 2024-03-07T00:25:38Z |
| format | Journal article |
| id | oxford-uuid:7e090f2d-565e-4cb7-9711-2d96ae0f38b2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:25:38Z |
| publishDate | 2018 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:7e090f2d-565e-4cb7-9711-2d96ae0f38b22022-03-26T21:08:00ZThe phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan AfricaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7e090f2d-565e-4cb7-9711-2d96ae0f38b2EnglishSymplectic Elements at OxfordSpringer Nature2018Park, SEPham, DTBoinett, CWong, VKPak, GDPanzner, UEspinoza, LMCVon Kalckreuth, VIm, JSchütt-Gerowitt, HCrump, JABreiman, RFAdu-Sarkodie, YOwusu-Dabo, ERakotozandrindrainy, RSoura, ABAseffa, AGasmelseed, NKeddy, KHMay, JSow, AGAaby, PBiggs, HMHertz, JTMontgomery, JMCosmas, LOlack, BFields, BSarpong, NRazafindrabe, TJLRaminosoa, TMKabore, LPSampo, ETeferi, MYeshitela, BTayeb, MASooka, AMeyer, CGKrumkamp, RDekker, DMJaeger, APoppert, STall, ANiang, ABjerregaard-Andersen, MLøfberg, SVSeo, HJJeon, HJDeerin, JFPark, JKonings, FAli, MClemens, JDHughes, PSendagala, JNVudriko, TDowning, RIkumapayi, UNMackenzie, GAObaro, SArgimon, SAanensen, DMPage, AKeane, JADuchene, SDyson, ZHolt, KEDougan, GMarks, FBaker, SThere is paucity of data regarding the geographical distribution, incidence, and phylogenetics of multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa. Here we present a phylogenetic reconstruction of whole genome sequenced 249 contemporaneous S. Typhi isolated between 2008-2015 in 11 sub-Saharan African countries, in context of the 2,057 global S. Typhi genomic framework. Despite the broad genetic diversity, the majority of organisms (225/249; 90%) belong to only three genotypes, 4.3.1 (H58) (99/249; 40%), 3.1.1 (97/249; 39%), and 2.3.2 (29/249; 12%). Genotypes 4.3.1 and 3.1.1 are confined within East and West Africa, respectively. MDR phenotype is found in over 50% of organisms restricted within these dominant genotypes. High incidences of MDR S. Typhi are calculated in locations with a high burden of typhoid, specifically in children aged <15 years. Antimicrobial stewardship, MDR surveillance, and the introduction of typhoid conjugate vaccines will be critical for the control of MDR typhoid in Africa. |
| spellingShingle | Park, SE Pham, DT Boinett, C Wong, VK Pak, GD Panzner, U Espinoza, LMC Von Kalckreuth, V Im, J Schütt-Gerowitt, H Crump, JA Breiman, RF Adu-Sarkodie, Y Owusu-Dabo, E Rakotozandrindrainy, R Soura, AB Aseffa, A Gasmelseed, N Keddy, KH May, J Sow, AG Aaby, P Biggs, HM Hertz, JT Montgomery, JM Cosmas, L Olack, B Fields, B Sarpong, N Razafindrabe, TJL Raminosoa, TM Kabore, LP Sampo, E Teferi, M Yeshitela, B Tayeb, MA Sooka, A Meyer, CG Krumkamp, R Dekker, DM Jaeger, A Poppert, S Tall, A Niang, A Bjerregaard-Andersen, M Løfberg, SV Seo, HJ Jeon, HJ Deerin, JF Park, J Konings, F Ali, M Clemens, JD Hughes, P Sendagala, JN Vudriko, T Downing, R Ikumapayi, UN Mackenzie, GA Obaro, S Argimon, S Aanensen, DM Page, A Keane, JA Duchene, S Dyson, Z Holt, KE Dougan, G Marks, F Baker, S The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa |
| title | The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa |
| title_full | The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa |
| title_fullStr | The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa |
| title_full_unstemmed | The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa |
| title_short | The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa |
| title_sort | phylogeography and incidence of multi drug resistant typhoid fever in sub saharan africa |
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