The effect of amitriptyline treatment on the growth hormone response to apomorphine.
The growth hormone response to subcutaneous administration of the dopamine agonist apomorphine (0.005 mg/kg) was assessed in six normal male subjects before and at the end of a course of amitriptyline. Amitriptyline treatment significantly reduced the growth hormone response to apomorphine, confirmi...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Springer-Verlag
1984
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| _version_ | 1826281238887923712 |
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| author | Cowen, P Braddock, L Gosden, B |
| author_facet | Cowen, P Braddock, L Gosden, B |
| author_sort | Cowen, P |
| collection | OXFORD |
| description | The growth hormone response to subcutaneous administration of the dopamine agonist apomorphine (0.005 mg/kg) was assessed in six normal male subjects before and at the end of a course of amitriptyline. Amitriptyline treatment significantly reduced the growth hormone response to apomorphine, confirming the findings of an earlier study in depressed patients. The way in which amitriptyline attenuates the effect of apomorphine is not clear. Direct blockade of dopamine receptors in the hypothalamus is a possibility, but long-term amitriptyline treatment could result in adaptive changes in the monoamine pathways which control GH release. |
| first_indexed | 2024-03-07T00:25:48Z |
| format | Journal article |
| id | oxford-uuid:7e1688e9-c5c4-4041-be49-2e0883d93cd7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:25:48Z |
| publishDate | 1984 |
| publisher | Springer-Verlag |
| record_format | dspace |
| spelling | oxford-uuid:7e1688e9-c5c4-4041-be49-2e0883d93cd72022-03-26T21:07:58ZThe effect of amitriptyline treatment on the growth hormone response to apomorphine.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7e1688e9-c5c4-4041-be49-2e0883d93cd7EnglishSymplectic Elements at OxfordSpringer-Verlag1984Cowen, PBraddock, LGosden, BThe growth hormone response to subcutaneous administration of the dopamine agonist apomorphine (0.005 mg/kg) was assessed in six normal male subjects before and at the end of a course of amitriptyline. Amitriptyline treatment significantly reduced the growth hormone response to apomorphine, confirming the findings of an earlier study in depressed patients. The way in which amitriptyline attenuates the effect of apomorphine is not clear. Direct blockade of dopamine receptors in the hypothalamus is a possibility, but long-term amitriptyline treatment could result in adaptive changes in the monoamine pathways which control GH release. |
| spellingShingle | Cowen, P Braddock, L Gosden, B The effect of amitriptyline treatment on the growth hormone response to apomorphine. |
| title | The effect of amitriptyline treatment on the growth hormone response to apomorphine. |
| title_full | The effect of amitriptyline treatment on the growth hormone response to apomorphine. |
| title_fullStr | The effect of amitriptyline treatment on the growth hormone response to apomorphine. |
| title_full_unstemmed | The effect of amitriptyline treatment on the growth hormone response to apomorphine. |
| title_short | The effect of amitriptyline treatment on the growth hormone response to apomorphine. |
| title_sort | effect of amitriptyline treatment on the growth hormone response to apomorphine |
| work_keys_str_mv | AT cowenp theeffectofamitriptylinetreatmentonthegrowthhormoneresponsetoapomorphine AT braddockl theeffectofamitriptylinetreatmentonthegrowthhormoneresponsetoapomorphine AT gosdenb theeffectofamitriptylinetreatmentonthegrowthhormoneresponsetoapomorphine AT cowenp effectofamitriptylinetreatmentonthegrowthhormoneresponsetoapomorphine AT braddockl effectofamitriptylinetreatmentonthegrowthhormoneresponsetoapomorphine AT gosdenb effectofamitriptylinetreatmentonthegrowthhormoneresponsetoapomorphine |