Redirecting pore assembly of staphylococcal α-hemolysin by protein engineering
α-Hemolysin (αHL), a β-barrel pore-forming toxin (βPFT), is secreted as a water-soluble monomer by Staphylococcus aureus. Upon binding to receptors on target cell membranes, αHL assembles to form heptameric membrane-spanning pores. We have previously engineered αHL to create a protease-activatable t...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Chemical Society
2019
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