Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial

Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial

Background: Hydroxychloroquine (HCQ) has proved ineffective in treating patients hospitalised with Coronavirus Disease 2019 (COVID-19), but uncertainty remains over its safety and efficacy in chemoprevention. Previous chemoprevention randomised controlled trials (RCTs) did not individually show bene...

Podrobná bibliografie
Hlavní autoři:	Schilling, WHK, Mukaka, M, Callery, JJ, Llewelyn, MJ, Cruz, CV, Dhorda, M, Ngernseng, T, Waithira, N, Ekkapongpisit, M, Watson, JA, Chandna, A, Nelwan, EJ, Hamers, RL, Etyang, A, Beg, MA, Sow, S, Yavo, W, Allabi, AC, Basnyat, B, Sharma, SK, Amofa-Sekyi, M, Yonga, P, Adler, A, Yuentrakul, P, Abdad, MY, Blacksell, SD, Tarning, J, Rahardjani, M, Rimainar, A, Akech, S, Hamaluba, M, Shrestha, S, Rijal, S, Woodrow, CJ, Cheah, PY, Taylor, WRJ, Batty, EM, von Seidlein, L, Dondorp, A, Day, NPJ, White, NJ
Médium:	Journal article
Jazyk:	English
Vydáno:	Public Library of Science 2024

Podobné jednotky

Chloroquine/ hydroxychloroquine prevention of coronavirus disease (COVID-19) in the healthcare setting; protocol for a randomised, placebo-controlled prophylaxis study (COPCOV)
Autor: Schilling, WHK, a další
Vydáno: (2020)

The WHO guideline on drugs to prevent COVID-19: small numbers- big conclusions
Autor: Schilling, WHK, a další
Vydáno: (2021)

Clinical antiviral efficacy of favipiravir in early COVID-19 (PLATCOV): an open-label, randomised, controlled, adaptive platform trial
Autor: Luvira, V, a další
Vydáno: (2024)

Pharmacometrics of high dose ivermectin in early COVID-19: an open label, randomized, controlled adaptive platform trial (PLATCOV)
Autor: Schilling, WHK, a další
Vydáno: (2023)

Clinical antiviral efficacy of remdesivir in coronavirus disease 2019: an open-label, randomized controlled adaptive platform trial (PLATCOV)
Autor: Jittamala, P, a další
Vydáno: (2023)

Common data elements for predictors of pediatric sepsis: A framework to standardize data collection
Autor: Mawji, A, a další
Vydáno: (2021)

Tackling post-discharge mortality in children living in LMICs to reduce child deaths
Autor: Akech, S, a další
Vydáno: (2023)

Antiviral efficacy of molnupiravir versus ritonavir-boosted nirmatrelvir in patients with early symptomatic COVID-19 (PLATCOV): an open-label, phase 2, randomised, controlled, adaptive trial
Autor: Schilling, WHK, a další
Vydáno: (2023)

Parasite clearance rates in Upper Myanmar indicate a distinctive artemisinin resistance phenotype: a therapeutic efficacy study.
Autor: Smithuis, F, a další
Vydáno: (2016)

SIGNIFIKANSI FATWA DSN MUI TERHADAP PERKEMBANGAN EKONOMI SYARIAH DI INDONESIA
Autor: M. Zaidi Abdad
Vydáno: (2020-02-01)

Analisis dan Pemetaan Pemikiran Fikih Moderat di Timur Tengah dan Relasinya dengan Gerakan Fikih Formalis
Autor: M Zaidi Abdad
Vydáno: (2011-01-01)

Defining the burden of febrile illness in rural South and Southeast Asia: an open letter to announce the launch of the Rural Febrile Illness project
Autor: Chandna, A, a další
Vydáno: (2021)

In vivo assessments to detect antimalarial resistance
Autor: Dhorda, M, a další
Vydáno: (2019)

Higher visual function deficits are independent of visual acuity measures in children with cerebral visual impairment
Autor: A. Chandna, a další
Vydáno: (2024-10-01)

Is triple artemisinin-based combination therapy necessary for uncomplicated malaria?
Autor: van der Pluijm, RW, a další
Vydáno: (2022)

Kadar Bilirubin Neonatus dengan dan Tanpa Defisiensi Glucose-6-Phosphate Dehydrogenase yang Mengalami atau Tidak Mengalami Infeksi
Autor: Kamilah Budhi Rahardjani
Vydáno: (2016-11-01)

Hubungan antara Malondialdehyde (MDA) dengan Hasil Luaran Sepsis Neonatorum
Autor: Kamilah Budhi Rahardjani
Vydáno: (2016-11-01)

Schistosoma japonicum complex: COI-sequences variations of parasites and their intermediate hosts analyzed using BLAST
Autor: M.L. Nelwan
Vydáno: (2024-12-01)

A systematic review of Hepatitis B virus (HBV) prevalence and genotypes in Kenya: Data to inform clinical care and health policy.
Autor: Louise O Downs, a další
Vydáno: (2023-01-01)

A systematic review of Hepatitis B virus (HBV) prevalence and genotypes in Kenya: Data to inform clinical care and health policy
Autor: Louise O. Downs, a další
Vydáno: (2023-01-01)

Where do those data go? Reuse of screening results from clinical trials to estimate population prevalence of HBV infection in adults in Kilifi, Kenya
Autor: Downs, LO, a další
Vydáno: (2023)

Prediction of disease severity in patients with febrile illnesses in resource-limited settings
Autor: Chandna, A
Vydáno: (2023)

The relationship between viral clearance rates and disease progression in early symptomatic COVID-19: a systematic review and meta-regression analysis
Autor: Singh, S, a další
Vydáno: (2024)

The Impact of Gas Flaring On Man and His Environment and the Way Out
Autor: A. Kwame Sekyi
Vydáno: (2017-09-01)

Defining the role of host biomarkers in the diagnosis and prognosis of the severity of childhood pneumonia: a prospective cohort study
Autor: Chandna, A, a další
Vydáno: (2023)

A systematic review of Hepatitis B virus (HBV) prevalence and genotypes in Kenya: data to inform clinical care and health policy
Autor: Downs, LO, a další
Vydáno: (2023)

Serotype-specific and age-dependent generation of pneumococcal polysaccharide-specific memory B-cell and antibody responses to immunization with a pneumococcal conjugate vaccine.
Autor: Clutterbuck, E, a další
Vydáno: (2008)

The impact of pulse oximetry on diagnosis, management and outcomes of acute febrile illness in low-income and middle-income countries: a systematic review
Autor: Chew, R, a další
Vydáno: (2021)

Obituary notice: Peter Arnold Lienhardt 1928-1986
Autor: W.R.J.
Vydáno: (1986)

Medical causes of admissions to hospital among adults in Africa: a systematic review.
Autor: Etyang, A, a další
Vydáno: (2013)

An Exploratory Study of Marketing Factors Influencing Fairtrade Food Buying Behaviour in the UK
Autor: Fred Amofa Yamoah
Vydáno: (2014-03-01)

An Exploratory Study of Marketing Factors Influencing Fairtrade Food Buying Behaviour in the UK
Autor: Fred Amofa Yamoah
Vydáno: (2013-12-01)

An Exploratory Study of Marketing Factors Influencing Fairtrade Food Buying Behaviour in the UK
Autor: Fred Amofa Yamoah
Vydáno: (2013-12-01)

AN EXPLORATORY STUDY OF MARKETING FACTORS INFLUENCING FAIRTRADE FOOD BUYING BEHAVIOUR IN THE UK
Autor: Fred Amofa Yamoah
Vydáno: (2014-01-01)

An Exploratory Study of Marketing Factors Influencing Fairtrade Food Buying Behaviour in the UK
Autor: Fred Amofa Yamoah
Vydáno: (2013-12-01)

Study protocol: an open-label individually randomised controlled trial to assess the efficacy of artemether-lumefantrine prophylaxis for malaria among forest goers in Cambodia
Autor: Maude, RJ, a další
Vydáno: (2021)

A multifaceted approach to a successful and sustainable hand hygiene campaign in a large tertiary academic medical centre
Autor: Yow O, a další
Vydáno: (2011-06-01)

A novel method to rapidly assess the suitability of water treatment residual and crushed concrete for the mitigation of point and nonpoint source nutrient pollution
Autor: O. Callery, a další
Vydáno: (2019-08-01)

Examining which clinicians provide admission hospital care in a high mortality setting and their adherence to guidelines: An observational study in 13 hospitals
Autor: Ogero, M, a další
Vydáno: (2020)

When to stay, when to go: trade-offs for southern African arid-zone birds in times of drought
Autor: W.R.J. Dean, a další
Vydáno: (2009-12-01)