Synthesis of anthraquinone oligonucleotides for triplex stabilization.
The synthesis of two anthraquinone phosphoramidites is described. In both cases the anthraquinone moiety is attached via a linker to the 5-position of a uracil base, allowing incorporation at any thymidine position in an oligonucleotide sequence. Anthraquinone-modified oligonucleotides have potentia...
| Autors principals: | , , , , |
|---|---|
| Format: | Journal article |
| Idioma: | English |
| Publicat: |
2007
|
| Sumari: | The synthesis of two anthraquinone phosphoramidites is described. In both cases the anthraquinone moiety is attached via a linker to the 5-position of a uracil base, allowing incorporation at any thymidine position in an oligonucleotide sequence. Anthraquinone-modified oligonucleotides have potential applications as triplex stabilizers and fluorescence quenchers. |
|---|