Synthesis of anthraquinone oligonucleotides for triplex stabilization.
The synthesis of two anthraquinone phosphoramidites is described. In both cases the anthraquinone moiety is attached via a linker to the 5-position of a uracil base, allowing incorporation at any thymidine position in an oligonucleotide sequence. Anthraquinone-modified oligonucleotides have potentia...
| Main Authors: | , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado: |
2007
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| _version_ | 1826281273651363840 |
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| author | Zhao, Z Peng, G Michels, J Fox, K Brown, T |
| author_facet | Zhao, Z Peng, G Michels, J Fox, K Brown, T |
| author_sort | Zhao, Z |
| collection | OXFORD |
| description | The synthesis of two anthraquinone phosphoramidites is described. In both cases the anthraquinone moiety is attached via a linker to the 5-position of a uracil base, allowing incorporation at any thymidine position in an oligonucleotide sequence. Anthraquinone-modified oligonucleotides have potential applications as triplex stabilizers and fluorescence quenchers. |
| first_indexed | 2024-03-07T00:26:20Z |
| format | Journal article |
| id | oxford-uuid:7e434d3c-7343-4d20-96fb-29a6ff5dd0d1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:26:20Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:7e434d3c-7343-4d20-96fb-29a6ff5dd0d12022-03-26T21:09:02ZSynthesis of anthraquinone oligonucleotides for triplex stabilization.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7e434d3c-7343-4d20-96fb-29a6ff5dd0d1EnglishSymplectic Elements at Oxford2007Zhao, ZPeng, GMichels, JFox, KBrown, TThe synthesis of two anthraquinone phosphoramidites is described. In both cases the anthraquinone moiety is attached via a linker to the 5-position of a uracil base, allowing incorporation at any thymidine position in an oligonucleotide sequence. Anthraquinone-modified oligonucleotides have potential applications as triplex stabilizers and fluorescence quenchers. |
| spellingShingle | Zhao, Z Peng, G Michels, J Fox, K Brown, T Synthesis of anthraquinone oligonucleotides for triplex stabilization. |
| title | Synthesis of anthraquinone oligonucleotides for triplex stabilization. |
| title_full | Synthesis of anthraquinone oligonucleotides for triplex stabilization. |
| title_fullStr | Synthesis of anthraquinone oligonucleotides for triplex stabilization. |
| title_full_unstemmed | Synthesis of anthraquinone oligonucleotides for triplex stabilization. |
| title_short | Synthesis of anthraquinone oligonucleotides for triplex stabilization. |
| title_sort | synthesis of anthraquinone oligonucleotides for triplex stabilization |
| work_keys_str_mv | AT zhaoz synthesisofanthraquinoneoligonucleotidesfortriplexstabilization AT pengg synthesisofanthraquinoneoligonucleotidesfortriplexstabilization AT michelsj synthesisofanthraquinoneoligonucleotidesfortriplexstabilization AT foxk synthesisofanthraquinoneoligonucleotidesfortriplexstabilization AT brownt synthesisofanthraquinoneoligonucleotidesfortriplexstabilization |