Enantioselective Copper(I)-Phosphoramidite Catalyzed Addition of Alkylzirconium Species to Acyclic Enones
Catalytic asymmetric conjugate addition reactions of alkylzirconium species to acyclic enones are reported. The alkylzirconium nucleophiles are generated in situ by hydrozirconation of alkenes with the Schwartz reagent. The reaction proceeds under mild and convenient conditions. A variety of functio...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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American Chemical Society
2015
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| _version_ | 1797078029627817984 |
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| author | Roth, P Fletcher, S |
| author_facet | Roth, P Fletcher, S |
| author_sort | Roth, P |
| collection | OXFORD |
| description | Catalytic asymmetric conjugate addition reactions of alkylzirconium species to acyclic enones are reported. The alkylzirconium nucleophiles are generated in situ by hydrozirconation of alkenes with the Schwartz reagent. The reaction proceeds under mild and convenient conditions. A variety of functionalized nucleophiles can be used, and the method tolerates some variation in enone scope. The method uses a new chiral nonracemic phosphoramidite ligand in a complex with copper triflate. |
| first_indexed | 2024-03-07T00:26:35Z |
| format | Journal article |
| id | oxford-uuid:7e591d5d-7826-4e19-81fc-c164e69502a0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:26:35Z |
| publishDate | 2015 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | oxford-uuid:7e591d5d-7826-4e19-81fc-c164e69502a02022-03-26T21:09:33ZEnantioselective Copper(I)-Phosphoramidite Catalyzed Addition of Alkylzirconium Species to Acyclic EnonesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7e591d5d-7826-4e19-81fc-c164e69502a0EnglishORA DepositAmerican Chemical Society2015Roth, PFletcher, SCatalytic asymmetric conjugate addition reactions of alkylzirconium species to acyclic enones are reported. The alkylzirconium nucleophiles are generated in situ by hydrozirconation of alkenes with the Schwartz reagent. The reaction proceeds under mild and convenient conditions. A variety of functionalized nucleophiles can be used, and the method tolerates some variation in enone scope. The method uses a new chiral nonracemic phosphoramidite ligand in a complex with copper triflate. |
| spellingShingle | Roth, P Fletcher, S Enantioselective Copper(I)-Phosphoramidite Catalyzed Addition of Alkylzirconium Species to Acyclic Enones |
| title | Enantioselective Copper(I)-Phosphoramidite Catalyzed Addition of Alkylzirconium Species to Acyclic Enones |
| title_full | Enantioselective Copper(I)-Phosphoramidite Catalyzed Addition of Alkylzirconium Species to Acyclic Enones |
| title_fullStr | Enantioselective Copper(I)-Phosphoramidite Catalyzed Addition of Alkylzirconium Species to Acyclic Enones |
| title_full_unstemmed | Enantioselective Copper(I)-Phosphoramidite Catalyzed Addition of Alkylzirconium Species to Acyclic Enones |
| title_short | Enantioselective Copper(I)-Phosphoramidite Catalyzed Addition of Alkylzirconium Species to Acyclic Enones |
| title_sort | enantioselective copper i phosphoramidite catalyzed addition of alkylzirconium species to acyclic enones |
| work_keys_str_mv | AT rothp enantioselectivecopperiphosphoramiditecatalyzedadditionofalkylzirconiumspeciestoacyclicenones AT fletchers enantioselectivecopperiphosphoramiditecatalyzedadditionofalkylzirconiumspeciestoacyclicenones |