Post-treatment and spontaneous HIV control
<p><strong>Purpose of review</strong> The aim of the current review is to explore the evidence around virological remission in ART-treated and untreated individuals living with HIV. With increasing evidence and interest in post-treatment control within the HIV-cure field, it is now...
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| Format: | Journal article |
| Language: | English |
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Wolters Kluwer Health
2018
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| Summary: | <p><strong>Purpose of review</strong> The aim of the current review is to explore the evidence around virological remission in ART-treated and untreated individuals living with HIV. With increasing evidence and interest in post-treatment control within the HIV-cure field, it is now increasingly important to agree on definitions to allow different ‘controller’ phenotypes to be clearly distinguished and mechanisms compared.</p> <p><strong>Recent findings</strong> This review explores recent data on potential predictors and mechanisms driving spontaneous and post-treatment control. We explore data on the role of the reservoir as a determinant of control and the challenges associated with its study, including the safety of treatment interruption. We explore options around deriving a consensus on how to define different forms of control and the longer term utility of achieving remission.</p> <p><strong>Summary</strong> Post-treatment control and remission following treatment interruption are becoming increasingly common measures of intervention efficacy in cure trials. As well as a need to show treatment interruption protocols are well tolerated and acceptable, for these measures to be robust and comparable between studies, clear and consensual definitions need to be agreed.</p> |
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