Post-treatment and spontaneous HIV control
<p><strong>Purpose of review</strong> The aim of the current review is to explore the evidence around virological remission in ART-treated and untreated individuals living with HIV. With increasing evidence and interest in post-treatment control within the HIV-cure field, it is now...
| Main Authors: | , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado: |
Wolters Kluwer Health
2018
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| _version_ | 1826281297714085888 |
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| author | Martin, G Frater, J |
| author_facet | Martin, G Frater, J |
| author_sort | Martin, G |
| collection | OXFORD |
| description | <p><strong>Purpose of review</strong> The aim of the current review is to explore the evidence around virological remission in ART-treated and untreated individuals living with HIV. With increasing evidence and interest in post-treatment control within the HIV-cure field, it is now increasingly important to agree on definitions to allow different ‘controller’ phenotypes to be clearly distinguished and mechanisms compared.</p> <p><strong>Recent findings</strong> This review explores recent data on potential predictors and mechanisms driving spontaneous and post-treatment control. We explore data on the role of the reservoir as a determinant of control and the challenges associated with its study, including the safety of treatment interruption. We explore options around deriving a consensus on how to define different forms of control and the longer term utility of achieving remission.</p> <p><strong>Summary</strong> Post-treatment control and remission following treatment interruption are becoming increasingly common measures of intervention efficacy in cure trials. As well as a need to show treatment interruption protocols are well tolerated and acceptable, for these measures to be robust and comparable between studies, clear and consensual definitions need to be agreed.</p> |
| first_indexed | 2024-03-07T00:26:41Z |
| format | Journal article |
| id | oxford-uuid:7e61d65e-1cd2-4bb5-be69-2a7331094a00 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:26:41Z |
| publishDate | 2018 |
| publisher | Wolters Kluwer Health |
| record_format | dspace |
| spelling | oxford-uuid:7e61d65e-1cd2-4bb5-be69-2a7331094a002022-03-26T21:09:45ZPost-treatment and spontaneous HIV controlJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7e61d65e-1cd2-4bb5-be69-2a7331094a00EnglishSymplectic Elements at OxfordWolters Kluwer Health2018Martin, GFrater, J<p><strong>Purpose of review</strong> The aim of the current review is to explore the evidence around virological remission in ART-treated and untreated individuals living with HIV. With increasing evidence and interest in post-treatment control within the HIV-cure field, it is now increasingly important to agree on definitions to allow different ‘controller’ phenotypes to be clearly distinguished and mechanisms compared.</p> <p><strong>Recent findings</strong> This review explores recent data on potential predictors and mechanisms driving spontaneous and post-treatment control. We explore data on the role of the reservoir as a determinant of control and the challenges associated with its study, including the safety of treatment interruption. We explore options around deriving a consensus on how to define different forms of control and the longer term utility of achieving remission.</p> <p><strong>Summary</strong> Post-treatment control and remission following treatment interruption are becoming increasingly common measures of intervention efficacy in cure trials. As well as a need to show treatment interruption protocols are well tolerated and acceptable, for these measures to be robust and comparable between studies, clear and consensual definitions need to be agreed.</p> |
| spellingShingle | Martin, G Frater, J Post-treatment and spontaneous HIV control |
| title | Post-treatment and spontaneous HIV control |
| title_full | Post-treatment and spontaneous HIV control |
| title_fullStr | Post-treatment and spontaneous HIV control |
| title_full_unstemmed | Post-treatment and spontaneous HIV control |
| title_short | Post-treatment and spontaneous HIV control |
| title_sort | post treatment and spontaneous hiv control |
| work_keys_str_mv | AT marting posttreatmentandspontaneoushivcontrol AT fraterj posttreatmentandspontaneoushivcontrol |