Myocardial ischaemia following COVID-19: a cardiovascular magnetic resonance study
The pathophysiology of myocardial injury following COVID-19 remains uncertain. COVID-HEART was a prospective, multicentre study utilising cardiovascular magnetic resonance (CMR) to characterise COVID-related myocardial injury. In this pre-specified analysis, the objectives were to examine (1) the fr...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Springer Netherlands
2024
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| _version_ | 1824459201057914880 |
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| author | Arnold, JR Yeo, JL Budgeon, CA Shergill, S England, R Shiwani, H Artico, J Moon, JC Gorecka, M Roditi, G Morrow, A Mangion, K Shanmuganathan, M Miller, CA Chiribiri, A Alzahir, M Ramirez, S Lin, A Swoboda, PP McDiarmid, AK Sykes, R Singh, T Bucciarelli-Ducci, C Dawson, D |
| author_facet | Arnold, JR Yeo, JL Budgeon, CA Shergill, S England, R Shiwani, H Artico, J Moon, JC Gorecka, M Roditi, G Morrow, A Mangion, K Shanmuganathan, M Miller, CA Chiribiri, A Alzahir, M Ramirez, S Lin, A Swoboda, PP McDiarmid, AK Sykes, R Singh, T Bucciarelli-Ducci, C Dawson, D |
| author_sort | Arnold, JR |
| collection | OXFORD |
| description | The pathophysiology of myocardial injury following COVID-19 remains uncertain. COVID-HEART was a prospective, multicentre study utilising cardiovascular magnetic resonance (CMR) to characterise COVID-related myocardial injury. In this pre-specified analysis, the objectives were to examine (1) the frequency of myocardial ischaemia following COVID-19, and (2) the association between ischaemia and myocardial injury. We studied 59 patients hospitalised with COVID-19 and elevated serum troponin (COVID + /troponin + , age 61 ± 11 years) and 37 control subjects without COVID-19 or elevated troponin and similar by age and cardiovascular comorbidities (COVID −/comorbidity + , 64 ± 10 years). Subjects underwent multi-parametric CMR (comprising assessment of ventricular volumes, stress perfusion, T1/T2 mapping and scar). The primary endpoint was the frequency of inducible myocardial ischaemia. Inducible ischaemia was evident in 11 (19%) COVID + /troponin + patients and in 8 (22%) control subjects (p = 0.72). In COVID + /troponin + patients with ischaemia, epicardial coronary disease pattern ischaemia was present in eight patients and microvascular disease pattern, in three patients. There was no significant difference in the frequency of inducible ischaemia in COVID + /troponin + patients with previous myocardial infarction and/or revascularisation compared to those without (2/12 [17%] vs. 9/47 [19%] respectively, p = 0.84), or in those with and without scar (7/27 [26%] vs. 4/32 [13%] respectively, p = 0.19). Myocardial ischaemia was present in ~ 20% of patients recently hospitalised with COVID-19 and with elevated cardiac troponin, but this was not different to matched comorbid controls. This finding coupled with the lack of an association between ischaemia and myocardial scar suggests that coronary artery abnormalities are unlikely to be the predominant mechanism underlying COVID-19 induced myocardial injury. |
| first_indexed | 2025-02-19T04:38:01Z |
| format | Journal article |
| id | oxford-uuid:7e85cb8a-59b4-4a6e-93ba-a1763e4ed889 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2025-02-19T04:38:01Z |
| publishDate | 2024 |
| publisher | Springer Netherlands |
| record_format | dspace |
| spelling | oxford-uuid:7e85cb8a-59b4-4a6e-93ba-a1763e4ed8892025-02-10T20:10:40ZMyocardial ischaemia following COVID-19: a cardiovascular magnetic resonance studyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7e85cb8a-59b4-4a6e-93ba-a1763e4ed889EnglishJisc Publications RouterSpringer Netherlands2024Arnold, JRYeo, JLBudgeon, CAShergill, SEngland, RShiwani, HArtico, JMoon, JCGorecka, MRoditi, GMorrow, AMangion, KShanmuganathan, MMiller, CAChiribiri, AAlzahir, MRamirez, SLin, ASwoboda, PPMcDiarmid, AKSykes, RSingh, TBucciarelli-Ducci, CDawson, DThe pathophysiology of myocardial injury following COVID-19 remains uncertain. COVID-HEART was a prospective, multicentre study utilising cardiovascular magnetic resonance (CMR) to characterise COVID-related myocardial injury. In this pre-specified analysis, the objectives were to examine (1) the frequency of myocardial ischaemia following COVID-19, and (2) the association between ischaemia and myocardial injury. We studied 59 patients hospitalised with COVID-19 and elevated serum troponin (COVID + /troponin + , age 61 ± 11 years) and 37 control subjects without COVID-19 or elevated troponin and similar by age and cardiovascular comorbidities (COVID −/comorbidity + , 64 ± 10 years). Subjects underwent multi-parametric CMR (comprising assessment of ventricular volumes, stress perfusion, T1/T2 mapping and scar). The primary endpoint was the frequency of inducible myocardial ischaemia. Inducible ischaemia was evident in 11 (19%) COVID + /troponin + patients and in 8 (22%) control subjects (p = 0.72). In COVID + /troponin + patients with ischaemia, epicardial coronary disease pattern ischaemia was present in eight patients and microvascular disease pattern, in three patients. There was no significant difference in the frequency of inducible ischaemia in COVID + /troponin + patients with previous myocardial infarction and/or revascularisation compared to those without (2/12 [17%] vs. 9/47 [19%] respectively, p = 0.84), or in those with and without scar (7/27 [26%] vs. 4/32 [13%] respectively, p = 0.19). Myocardial ischaemia was present in ~ 20% of patients recently hospitalised with COVID-19 and with elevated cardiac troponin, but this was not different to matched comorbid controls. This finding coupled with the lack of an association between ischaemia and myocardial scar suggests that coronary artery abnormalities are unlikely to be the predominant mechanism underlying COVID-19 induced myocardial injury. |
| spellingShingle | Arnold, JR Yeo, JL Budgeon, CA Shergill, S England, R Shiwani, H Artico, J Moon, JC Gorecka, M Roditi, G Morrow, A Mangion, K Shanmuganathan, M Miller, CA Chiribiri, A Alzahir, M Ramirez, S Lin, A Swoboda, PP McDiarmid, AK Sykes, R Singh, T Bucciarelli-Ducci, C Dawson, D Myocardial ischaemia following COVID-19: a cardiovascular magnetic resonance study |
| title | Myocardial ischaemia following COVID-19: a cardiovascular magnetic resonance study |
| title_full | Myocardial ischaemia following COVID-19: a cardiovascular magnetic resonance study |
| title_fullStr | Myocardial ischaemia following COVID-19: a cardiovascular magnetic resonance study |
| title_full_unstemmed | Myocardial ischaemia following COVID-19: a cardiovascular magnetic resonance study |
| title_short | Myocardial ischaemia following COVID-19: a cardiovascular magnetic resonance study |
| title_sort | myocardial ischaemia following covid 19 a cardiovascular magnetic resonance study |
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