Imaging DNA damage allows detection of preneoplasia in the BALB-neuT model of breast cancer.
A prominent feature of many human cancers is oncogene-driven activation of the DNA damage response (DDR) during early tumorigenesis. It has been shown previously that noninvasive imaging of the phosphorylated histone H2A variant H2AX, γH2AX, a DNA damage signaling protein, is possible using (111)In-...
Main Authors: | Cornelissen, B, Able, S, Kartsonaki, C, Kersemans, V, Allen, P, Cavallo, F, Cazier, J, Iezzi, M, Knight, J, Muschel, R, Smart, S, Vallis, K |
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Format: | Journal article |
Language: | English |
Published: |
Society of Nuclear Medicine
2014
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