The role of LMO2 in development and in T cell leukemia after chromosomal translocation or retroviral insertion.

The role of LMO2 in development and in T cell leukemia after chromosomal translocation or retroviral insertion.

Chromosomal translocations are primary events in the development of leukemias, representing at least one genetic feature of the putative cancer stem cell. Studies of genes influenced by chromosomal translocations have yielded a vast amount of information about how cancer is initiated and maintained....

書誌詳細
主要な著者:	Nam, C, Rabbitts, T
フォーマット:	Journal article
言語:	English
出版事項:	2006

類似資料

The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development.
著者:: McCormack, M, 等
出版事項: (2003)

Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy.
著者:: Utpal P Davé, 等
出版事項: (2009-05-01)

Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency.
著者:: McCormack, M, 等
出版事項: (2004)

The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal.
著者:: McCormack, M, 等
出版事項: (2010)

High frequency of cryptic chromosomal rearrangements involving the LMO2 gene in T-cell acute lymphoblastic leukemia
著者:: Lili Wu, 等
出版事項: (2015-06-01)

Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice.
著者:: Tse, E, 等
出版事項: (2004)

T cell tumorigenesis in Lmo2 transgenic mice is independent of V-D-J recombinase activity.
著者:: Drynan, L, 等
出版事項: (2001)

An antibody inhibitor of the LMO2-protein complex blocks its normal and tumorigenic functions.
著者:: Nam, C, 等
出版事項: (2008)

Chromosomal translocation master genes, mouse models and experimental therapeutics.
著者:: Rabbitts, T
出版事項: (2001)

Modeling chromosomal translocations using conditional alleles to recapitulate initiating events in human leukemias.
著者:: Lobato, M, 等
出版事項: (2008)

Surfaceome interrogation using an RNA-seq approach highlights leukemia initiating cell biomarkers in an LMO2 T cell transgenic model
著者:: Pais, H, 等
出版事項: (2019)

Identification of a high incidence region for retroviral vector integration near exon 1 of the <it>LMO2 </it>locus
著者:: Sakashita Kazuo, 等
出版事項: (2009-09-01)

Chromosomal translocation products engender new intracellular therapeutic technologies.
著者:: Rabbitts, T, 等
出版事項: (2003)

Targeting LMO2 with a peptide aptamer establishes a necessary function in overt T-cell neoplasia.
著者:: Appert, A, 等
出版事項: (2009)

The oncogenic LIM-only transcription factor Lmo2 regulates angiogenesis but not vasculogenesis in mice.
著者:: Yamada, Y, 等
出版事項: (2000)

Mutation of C/EBPalpha predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen.
著者:: Hasemann, MS, 等
出版事項: (2008)

The promiscuous MLL gene links chromosomal translocations to cellular differentiation and tumour tropism.
著者:: Collins, E, 等
出版事項: (2002)

LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.
著者:: Stephen Smith, 等
出版事項: (2014-01-01)

The transcription factor complex LMO2/TAL1 regulates branching and endothelial cell migration in sprouting angiogenesis
著者:: Yoshihiro Yamada, 等
出版事項: (2022-05-01)

Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL.
著者:: McCormack, M, 等
出版事項: (2013)

Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemia.
著者:: Collins, E, 等
出版事項: (2002)

Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1.
著者:: Gering, M, 等
出版事項: (2003)

ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms
著者:: Steven Goossens, 等
出版事項: (2019-08-01)

LMO2 and IL2RG synergize in thymocytes to mimic the evolution of SCID-X1 gene therapy-associated T-cell leukaemia
著者:: Ruggero, K, 等
出版事項: (2016)

LMO2 and IL2RG synergize in thymocytes to mimic the evolution of SCID-X1 gene therapy-associated T-cell leukaemia
著者:: Ruggero, K, 等
出版事項: (2016)

Diagnostic utility of LMO2 immunohistochemistry in distinguishing T-lymphoblastic leukemia/lymphoma from thymoma
著者:: Divya Bansal, 等
出版事項: (2023-01-01)

Chromosomal translocation engineering to recapitulate primary events of human cancer.
著者:: Forster, A, 等
出版事項: (2005)

The LIM-domain protein Lmo2 is a key regulator of tumour angiogenesis: a new anti-angiogenesis drug target.
著者:: Yamada, Y, 等
出版事項: (2002)

Application of Chromosome Conformation Capture Method for Detection MYC/TRD Chromosomal Translocation in Leukemia Cell Line
著者:: Moloud Absalan, 等
出版事項: (2020-07-01)

Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex
著者:: Sewell, H, 等
出版事項: (2014)

Nonreciprocal chromosomal translocations in renal cancer involve multiple DSBs and NHEJ associated with breakpoint inversion but not necessarily with transcription.
著者:: Ali, H, 等
出版事項: (2013)

Nonreciprocal chromosomal translocations in renal cancer involve multiple DSBs and NHEJ associated with breakpoint inversion but not necessarily with transcription
著者:: Ali, H, 等
出版事項: (2013)

Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia
著者:: Rahman, Sunniyat, 等
出版事項: (2018)

Characterization of a pediatric T-cell acute lymphoblastic leukemia patient with simultaneous LYL1 and LMO2 rearrangements
著者:: Irene Homminga, 等
出版事項: (2012-02-01)

Ku70 affects the frequency of chromosome translocation in human lymphocytes after radiation and T-cell acute lymphoblastic leukemia
著者:: Zhenbo Cheng, 等
出版事項: (2022-08-01)

Structure of the leukemia oncogene LMO2: implications for the assembly of a hematopoietic transcription factor complex.
著者:: El Omari, K, 等
出版事項: (2011)

Preclinical modeling of cytosine arabinoside response in Mll-Enl translocator mouse leukemias.
著者:: Cano, F, 等
出版事項: (2008)

Deletion, insertion and translocation of DNA sequences contribute to chromosome size polimorphism in Plasmodium berghei
著者:: Chris J. Janse, 等
出版事項: (1992-01-01)

Detecting statistically significant common insertion sites in retroviral insertional mutagenesis screens.
著者:: Jeroen de Ridder, 等
出版事項: (2006-12-01)

Adult T-cell leukemia/lymphoma: A retroviral malady
著者:: Anza Khader, 等
出版事項: (2012-01-01)